node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
XDD1_2715 | bioF | XDD1_2715 | XDD1_1474 | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.535 |
XDD1_2715 | hldD | XDD1_2715 | XDD1_0146 | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.562 |
XDD1_2715 | kbl | XDD1_2715 | XDD1_0147 | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.535 |
XDD1_2715 | tdh | XDD1_2715 | XDD1_0148 | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.505 |
XDD1_2715 | ydfG | XDD1_2715 | XDD1_2170 | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.595 |
bioF | XDD1_2715 | XDD1_1474 | XDD1_2715 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | 0.535 |
bioF | tdh | XDD1_1474 | XDD1_0148 | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.530 |
hldD | XDD1_2715 | XDD1_0146 | XDD1_2715 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | 0.562 |
hldD | kbl | XDD1_0146 | XDD1_0147 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.501 |
hldD | rfaC | XDD1_0146 | XDD1_0144 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | Lipopolysaccharide heptosyltransferase 1. | 0.919 |
hldD | rfaF | XDD1_0146 | XDD1_0145 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | ADP-heptose--LPS heptosyltransferase 2. | 0.969 |
hldD | tdh | XDD1_0146 | XDD1_0148 | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.466 |
ilvA | tdh | XDD1_0333 | XDD1_0148 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.902 |
ilvA | thrC | XDD1_0333 | XDD1_0778 | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Threonine synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.953 |
kbl | XDD1_2715 | XDD1_0147 | XDD1_2715 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Polyketide synthase modules and related protein; Function of strongly homologous gene; enzyme. | 0.535 |
kbl | hldD | XDD1_0147 | XDD1_0146 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | ADP-L-glycero-D-manno-heptose-6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. | 0.501 |
kbl | rfaC | XDD1_0147 | XDD1_0144 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | Lipopolysaccharide heptosyltransferase 1. | 0.462 |
kbl | rfaF | XDD1_0147 | XDD1_0145 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | ADP-heptose--LPS heptosyltransferase 2. | 0.458 |
kbl | tdh | XDD1_0147 | XDD1_0148 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.995 |
kbl | ydfG | XDD1_0147 | XDD1_2170 | 2-amino-3-ketobutyrate CoA ligase (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.900 |