node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ORA75502.1 | ORA82282.1 | BST28_21925 | BST28_04665 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.704 |
ORA75502.1 | arc | BST28_21925 | BST28_04650 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.830 |
ORA75502.1 | pafA | BST28_21925 | BST28_00285 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.752 |
ORA75502.1 | prcA | BST28_21925 | BST28_04680 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.999 |
ORA75502.1 | prcB | BST28_21925 | BST28_04675 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.979 |
ORA75502.1 | pup | BST28_21925 | BST28_04670 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.722 |
ORA82282.1 | ORA75502.1 | BST28_04665 | BST28_21925 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.704 |
ORA82282.1 | arc | BST28_04665 | BST28_04650 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.877 |
ORA82282.1 | pafA | BST28_04665 | BST28_00285 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.840 |
ORA82282.1 | panB | BST28_04665 | BST28_13170 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. | 0.402 |
ORA82282.1 | prcA | BST28_04665 | BST28_04680 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.960 |
ORA82282.1 | prcB | BST28_04665 | BST28_04675 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.958 |
ORA82282.1 | pup | BST28_04665 | BST28_04670 | Proteasome accessory factor PafA2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ubiquitin-like protein Pup; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. | 0.960 |
ORA83375.1 | ORA83579.1 | BST28_00280 | BST28_00275 | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Protein pafC; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |
ORA83375.1 | arc | BST28_00280 | BST28_04650 | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. | 0.462 |
ORA83375.1 | pafA | BST28_00280 | BST28_00285 | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pup--protein ligase; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. | 0.931 |
ORA83375.1 | prcA | BST28_00280 | BST28_04680 | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. | 0.579 |
ORA83375.1 | prcB | BST28_00280 | BST28_04675 | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. | 0.436 |
ORA83375.1 | tatA | BST28_00280 | BST28_00270 | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sec-independent protein translocase TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. | 0.753 |
ORA83579.1 | ORA83375.1 | BST28_00275 | BST28_00280 | Protein pafC; Derived by automated computational analysis using gene prediction method: Protein Homology. | WYL domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.998 |