node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEO92065.1 | SEP29167.1 | SAMN05660816_03842 | SAMN05660816_05079 | Hypothetical protein. | Dihydrofolate reductase. | 0.540 |
SEO92065.1 | SEP31800.1 | SAMN05660816_03842 | SAMN05660816_05265 | Hypothetical protein. | Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.447 |
SEO98866.1 | SEP29167.1 | SAMN05660816_04078 | SAMN05660816_05079 | Dihydropteroate synthase. | Dihydrofolate reductase. | 0.409 |
SEO98866.1 | glyA | SAMN05660816_04078 | SAMN05660816_06292 | Dihydropteroate synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.650 |
SEO98866.1 | thyA | SAMN05660816_04078 | SAMN05660816_06209 | Dihydropteroate synthase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.609 |
SEO98866.1 | tmk | SAMN05660816_04078 | SAMN05660816_00796 | Dihydropteroate synthase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.561 |
SEP29167.1 | SEO92065.1 | SAMN05660816_05079 | SAMN05660816_03842 | Dihydrofolate reductase. | Hypothetical protein. | 0.540 |
SEP29167.1 | SEO98866.1 | SAMN05660816_05079 | SAMN05660816_04078 | Dihydrofolate reductase. | Dihydropteroate synthase. | 0.409 |
SEP29167.1 | SEP31800.1 | SAMN05660816_05079 | SAMN05660816_05265 | Dihydrofolate reductase. | Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.407 |
SEP29167.1 | dut | SAMN05660816_05079 | SAMN05660816_00094 | Dihydrofolate reductase. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.408 |
SEP29167.1 | glyA | SAMN05660816_05079 | SAMN05660816_06292 | Dihydrofolate reductase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.413 |
SEP29167.1 | thyA | SAMN05660816_05079 | SAMN05660816_06209 | Dihydrofolate reductase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.825 |
SEP29167.1 | tmk | SAMN05660816_05079 | SAMN05660816_00796 | Dihydrofolate reductase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.409 |
SEP31800.1 | SEO92065.1 | SAMN05660816_05265 | SAMN05660816_03842 | Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Hypothetical protein. | 0.447 |
SEP31800.1 | SEP29167.1 | SAMN05660816_05265 | SAMN05660816_05079 | Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Dihydrofolate reductase. | 0.407 |
SEP31800.1 | glyA | SAMN05660816_05265 | SAMN05660816_06292 | Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.865 |
SEP31800.1 | tmk | SAMN05660816_05265 | SAMN05660816_00796 | Amino acid adenylation domain-containing protein; Belongs to the ATP-dependent AMP-binding enzyme family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.435 |
dut | SEP29167.1 | SAMN05660816_00094 | SAMN05660816_05079 | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Dihydrofolate reductase. | 0.408 |
dut | thyA | SAMN05660816_00094 | SAMN05660816_06209 | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.980 |
dut | tmk | SAMN05660816_00094 | SAMN05660816_00796 | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.905 |