SIR76396.1 protein (Mucilaginibacter lappiensis)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SIR76396.1

Four helix bundle protein. (107 aa)

Predicted Functional Partners:

SIQ37940.1

0.775

SIR97062.1

0.775

SIR76413.1

0.572

SIR76437.1

0.572

miaB

0.544

SIR76454.1

0.525

SIR66690.1

0.520

SIR76470.1

0.518

Your Current Organism:

Mucilaginibacter lappiensis

NCBI taxonomy Id: 354630
Other names: LMG 25358, LMG:25358, M. lappiensis, Mucilaginibacter lappiensis Mannisto et al. 2010, Mucilaginibacter sp. ANJLI2, Mucilaginibacter sp. MP601, Mucilaginibacter sp. RA1BR4, Sphingobacteriaceae bacterium ANJLI2, strain ANJLI2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIQ37940.1	SIR66690.1	SAMN05421821_102324	SAMN05421821_11010	Four helix bundle protein.	Four helix bundle protein.	0.450
SIQ37940.1	SIR76396.1	SAMN05421821_102324	SAMN05421821_111181	Four helix bundle protein.	Four helix bundle protein.	0.775
SIQ37940.1	SIR97062.1	SAMN05421821_102324	SAMN05421821_11722	Four helix bundle protein.	Four helix bundle protein.	0.775
SIR66690.1	SIQ37940.1	SAMN05421821_11010	SAMN05421821_102324	Four helix bundle protein.	Four helix bundle protein.	0.450
SIR66690.1	SIR76396.1	SAMN05421821_11010	SAMN05421821_111181	Four helix bundle protein.	Four helix bundle protein.	0.520
SIR66690.1	SIR97062.1	SAMN05421821_11010	SAMN05421821_11722	Four helix bundle protein.	Four helix bundle protein.	0.591
SIR76396.1	SIQ37940.1	SAMN05421821_111181	SAMN05421821_102324	Four helix bundle protein.	Four helix bundle protein.	0.775
SIR76396.1	SIR66690.1	SAMN05421821_111181	SAMN05421821_11010	Four helix bundle protein.	Four helix bundle protein.	0.520
SIR76396.1	SIR76413.1	SAMN05421821_111181	SAMN05421821_111182	Four helix bundle protein.	Transcriptional regulator.	0.572
SIR76396.1	SIR76437.1	SAMN05421821_111181	SAMN05421821_111183	Four helix bundle protein.	Lipopolysaccharide-assembly.	0.572
SIR76396.1	SIR76454.1	SAMN05421821_111181	SAMN05421821_111184	Four helix bundle protein.	Hypothetical protein.	0.525
SIR76396.1	SIR76470.1	SAMN05421821_111181	SAMN05421821_111185	Four helix bundle protein.	Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.	0.518
SIR76396.1	SIR97062.1	SAMN05421821_111181	SAMN05421821_11722	Four helix bundle protein.	Four helix bundle protein.	0.775
SIR76396.1	miaB	SAMN05421821_111181	SAMN05421821_111180	Four helix bundle protein.	tRNA-2-methylthio-N6-dimethylallyladenosine synthase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.	0.544
SIR76413.1	SIR76396.1	SAMN05421821_111182	SAMN05421821_111181	Transcriptional regulator.	Four helix bundle protein.	0.572
SIR76413.1	SIR76437.1	SAMN05421821_111182	SAMN05421821_111183	Transcriptional regulator.	Lipopolysaccharide-assembly.	0.836
SIR76413.1	SIR76454.1	SAMN05421821_111182	SAMN05421821_111184	Transcriptional regulator.	Hypothetical protein.	0.780
SIR76413.1	SIR76470.1	SAMN05421821_111182	SAMN05421821_111185	Transcriptional regulator.	Preprotein translocase subunit SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family.	0.766
SIR76413.1	miaB	SAMN05421821_111182	SAMN05421821_111180	Transcriptional regulator.	tRNA-2-methylthio-N6-dimethylallyladenosine synthase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.	0.480
SIR76437.1	SIR76396.1	SAMN05421821_111183	SAMN05421821_111181	Lipopolysaccharide-assembly.	Four helix bundle protein.	0.572

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Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.958

expected number of edges:

28

PPI enrichment p-value:

0.000288

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 362

1.8

4.85

1.50e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 174

2.12

7.38

1.90e-20

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

9 of 82

2.36

7.78

3.79e-18

GO:0044391

Ribosomal subunit

10 of 151

2.14

6.98

1.54e-18

GO:0005840

Ribosome

11 of 204

2.05

6.89

4.88e-20

GO:0005762

Mitochondrial large ribosomal subunit

7 of 53

2.44

6.41

4.89e-14

GO:0098798

Mitochondrial protein-containing complex

9 of 274

1.83

4.52

5.76e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4633

Organellar large ribosomal subunit, and Ribosomal protein L23

9 of 25

2.87

10.51

3.01e-21

CL:4635

Organellar large ribosomal subunit, and Ribosomal protein L23

8 of 20

2.92

9.73

1.95e-19

CL:4506

Mitochondrial translation elongation

10 of 95

2.34

8.41

3.61e-20

CL:4660

Mixed, incl. Ribosomal protein S12/S23, and Ribosomal protein L14p/L23e

5 of 7

3.17

6.19

4.34e-12

CL:4637

Ribosomal protein L23, and Organellar large ribosomal subunit

3 of 8

2.89

2.8

7.53e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lco03010

Ribosome

10 of 121

2.24

7.88

4.80e-20

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5389840

Mitochondrial translation elongation

9 of 93

2.3

7.21

4.37e-17

MAP-5419276

Mitochondrial translation termination

9 of 94

2.3

7.19

4.37e-17

MAP-5368287

Mitochondrial translation

9 of 100

2.27

7.1

4.37e-17

MAP-72766

Translation

10 of 337

1.79

4.59

2.54e-15

MAP-392499

Metabolism of proteins

10 of 2732

0.88

0.92

1.95e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

11 of 154

2.17

7.89

2.99e-21

GOCC:0005761

Mitochondrial ribosome

9 of 78

2.38

7.89

3.03e-18

GOCC:0044391

Ribosomal subunit

10 of 118

2.25

7.76

1.76e-19

GOCC:0005762

Mitochondrial large ribosomal subunit

7 of 47

2.49

6.7

1.81e-14

GOCC:0098798

Mitochondrial protein complex

9 of 228

1.91

4.96

1.63e-14

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 159

2.16

7.93

9.70e-22

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