Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (970 aa)    
Predicted Functional Partners:
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 0.999
gcvP-2
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
0.999
SEQ06318.1
Aminomethyltransferase.
 0.998
SEQ13285.1
Sarcosine oxidase subunit alpha; Belongs to the GcvT family.
  
 0.998
gcvH-2
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 0.998
SEQ05395.1
Sarcosine oxidase subunit alpha; Belongs to the GcvT family.
  
 0.996
SEQ09568.1
Aminomethyltransferase; Belongs to the GcvT family.
 
 0.996
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
 0.996
SEQ80206.1
Aminomethyltransferase; Belongs to the GcvT family.
 
 0.982
SEQ60680.1
Fumarase, class I, homodimeric; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
   
  
 0.974
Your Current Organism:
Amphritea atlantica
NCBI taxonomy Id: 355243
Other names: A. atlantica, Amphritea atlantica Gartner et al. 2008 emend. Jang et al. 2015, DSM 18887, LMG 24143, LMG:24143, gamma proteobacterium M41, strain M41
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