| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEQ21944.1 | htpX | SAMN03080615_00754 | SAMN03080615_01433 | Modulator of FtsH protease; Belongs to the BI1 family. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.417 |
| SEQ41211.1 | SEQ41231.1 | SAMN03080615_01431 | SAMN03080615_01432 | Hypothetical protein. | 23S rRNA (cytosine1962-C5)-methyltransferase; Belongs to the methyltransferase superfamily. | 0.640 |
| SEQ41211.1 | htpX | SAMN03080615_01431 | SAMN03080615_01433 | Hypothetical protein. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.442 |
| SEQ41231.1 | SEQ41211.1 | SAMN03080615_01432 | SAMN03080615_01431 | 23S rRNA (cytosine1962-C5)-methyltransferase; Belongs to the methyltransferase superfamily. | Hypothetical protein. | 0.640 |
| SEQ41231.1 | htpX | SAMN03080615_01432 | SAMN03080615_01433 | 23S rRNA (cytosine1962-C5)-methyltransferase; Belongs to the methyltransferase superfamily. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.522 |
| SEQ57373.1 | ftsH | SAMN03080615_01944 | SAMN03080615_03893 | Murein DD-endopeptidase. | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.408 |
| SEQ57373.1 | htpX | SAMN03080615_01944 | SAMN03080615_01433 | Murein DD-endopeptidase. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.470 |
| SEQ60848.1 | grpE | SAMN03080615_02105 | SAMN03080615_01138 | UPF0716 protein FxsA. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.405 |
| SEQ60848.1 | htpX | SAMN03080615_02105 | SAMN03080615_01433 | UPF0716 protein FxsA. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.425 |
| SEQ66016.1 | htpX | SAMN03080615_02233 | SAMN03080615_01433 | Uncharacterized membrane protein YebE, DUF533 family. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.455 |
| SER07560.1 | htpX | SAMN03080615_03828 | SAMN03080615_01433 | Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.453 |
| ftsH | SEQ57373.1 | SAMN03080615_03893 | SAMN03080615_01944 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Murein DD-endopeptidase. | 0.408 |
| ftsH | grpE | SAMN03080615_03893 | SAMN03080615_01138 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.645 |
| ftsH | htpX | SAMN03080615_03893 | SAMN03080615_01433 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.505 |
| ftsH | lon | SAMN03080615_03893 | SAMN03080615_02347 | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.764 |
| grpE | SEQ60848.1 | SAMN03080615_01138 | SAMN03080615_02105 | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | UPF0716 protein FxsA. | 0.405 |
| grpE | ftsH | SAMN03080615_01138 | SAMN03080615_03893 | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | Membrane protease FtsH catalytic subunit; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.645 |
| grpE | htpX | SAMN03080615_01138 | SAMN03080615_01433 | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | Heat shock protein HtpX; Belongs to the peptidase M48B family. | 0.486 |
| grpE | lon | SAMN03080615_01138 | SAMN03080615_02347 | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.849 |
| htpX | SEQ21944.1 | SAMN03080615_01433 | SAMN03080615_00754 | Heat shock protein HtpX; Belongs to the peptidase M48B family. | Modulator of FtsH protease; Belongs to the BI1 family. | 0.417 |
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