| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SEQ29238.1 | SEQ93510.1 | SAMN03080615_01076 | SAMN03080615_03318 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.622 |
| SEQ29238.1 | glyA-3 | SAMN03080615_01076 | SAMN03080615_01068 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.457 |
| SEQ30669.1 | SEQ31492.1 | SAMN03080615_01141 | SAMN03080615_01176 | Serine O-acetyltransferase. | Homoserine dehydrogenase. | 0.758 |
| SEQ30669.1 | SEQ76507.1 | SAMN03080615_01141 | SAMN03080615_02689 | Serine O-acetyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.709 |
| SEQ30669.1 | SEQ93510.1 | SAMN03080615_01141 | SAMN03080615_03318 | Serine O-acetyltransferase. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.597 |
| SEQ30669.1 | glyA | SAMN03080615_01141 | SAMN03080615_00194 | Serine O-acetyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.526 |
| SEQ30669.1 | glyA-2 | SAMN03080615_01141 | SAMN03080615_00245 | Serine O-acetyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.526 |
| SEQ30669.1 | glyA-3 | SAMN03080615_01141 | SAMN03080615_01068 | Serine O-acetyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.526 |
| SEQ31492.1 | SEQ30669.1 | SAMN03080615_01176 | SAMN03080615_01141 | Homoserine dehydrogenase. | Serine O-acetyltransferase. | 0.758 |
| SEQ31492.1 | SEQ76507.1 | SAMN03080615_01176 | SAMN03080615_02689 | Homoserine dehydrogenase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.980 |
| SEQ31492.1 | SEQ93510.1 | SAMN03080615_01176 | SAMN03080615_03318 | Homoserine dehydrogenase. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.762 |
| SEQ31492.1 | glyA | SAMN03080615_01176 | SAMN03080615_00194 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.550 |
| SEQ31492.1 | glyA-2 | SAMN03080615_01176 | SAMN03080615_00245 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.550 |
| SEQ31492.1 | glyA-3 | SAMN03080615_01176 | SAMN03080615_01068 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.550 |
| SEQ31492.1 | hisF | SAMN03080615_01176 | SAMN03080615_00901 | Homoserine dehydrogenase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.524 |
| SEQ31492.1 | hisZ | SAMN03080615_01176 | SAMN03080615_03760 | Homoserine dehydrogenase. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.448 |
| SEQ31492.1 | serC | SAMN03080615_01176 | SAMN03080615_02945 | Homoserine dehydrogenase. | Phosphoserine aminotransferase apoenzyme; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.832 |
| SEQ76507.1 | SEQ30669.1 | SAMN03080615_02689 | SAMN03080615_01141 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine O-acetyltransferase. | 0.709 |
| SEQ76507.1 | SEQ31492.1 | SAMN03080615_02689 | SAMN03080615_01176 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.980 |
| SEQ76507.1 | SEQ93510.1 | SAMN03080615_02689 | SAMN03080615_03318 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | HAD-superfamily subfamily IB hydrolase, TIGR01490. | 0.704 |
