EOG090X09ZA protein (Daphnia magna) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

EOG090X09ZA

Protein MEMO1. (294 aa)

Predicted Functional Partners:

APZ42_030647

0.894

APZ42_020791

0.798

APZ42_024857

0.728

EOG090X09EZ

0.713

APZ42_020986

0.710

APZ42_012615

0.702

APZ42_004669

0.702

APZ42_002734

0.672

APZ42_032195

0.672

APZ42_003207

0.639

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002734	APZ42_004669	A0A164I2R4	A0A164GWT3	Pro-neuregulin-2, membrane-bound.	Ras GTP-binding protein Rho1.	0.581
APZ42_002734	APZ42_012615	A0A164I2R4	A0A0P5KP21	Pro-neuregulin-2, membrane-bound.	Rho-related GTP-binding protein RhoF.	0.581
APZ42_002734	APZ42_024857	A0A164I2R4	A0A164TND3	Pro-neuregulin-2, membrane-bound.	Receptor protein-tyrosine kinase.	0.969
APZ42_002734	EOG090X09ZA	A0A164I2R4	A0A0P5G1N1	Pro-neuregulin-2, membrane-bound.	Protein MEMO1.	0.672
APZ42_003207	EOG090X09ZA	A0A162C394	A0A0P5G1N1	Oxidored_molyb domain-containing protein.	Protein MEMO1.	0.639
APZ42_004669	APZ42_002734	A0A164GWT3	A0A164I2R4	Ras GTP-binding protein Rho1.	Pro-neuregulin-2, membrane-bound.	0.581
APZ42_004669	APZ42_024857	A0A164GWT3	A0A164TND3	Ras GTP-binding protein Rho1.	Receptor protein-tyrosine kinase.	0.762
APZ42_004669	APZ42_032195	A0A164GWT3	A0A164M896	Ras GTP-binding protein Rho1.	Pro-neuregulin-2, membrane-bound-like protein.	0.581
APZ42_004669	EOG090X09ZA	A0A164GWT3	A0A0P5G1N1	Ras GTP-binding protein Rho1.	Protein MEMO1.	0.702
APZ42_012615	APZ42_002734	A0A0P5KP21	A0A164I2R4	Rho-related GTP-binding protein RhoF.	Pro-neuregulin-2, membrane-bound.	0.581
APZ42_012615	APZ42_024857	A0A0P5KP21	A0A164TND3	Rho-related GTP-binding protein RhoF.	Receptor protein-tyrosine kinase.	0.762
APZ42_012615	APZ42_032195	A0A0P5KP21	A0A164M896	Rho-related GTP-binding protein RhoF.	Pro-neuregulin-2, membrane-bound-like protein.	0.581
APZ42_012615	EOG090X09ZA	A0A0P5KP21	A0A0P5G1N1	Rho-related GTP-binding protein RhoF.	Protein MEMO1.	0.702
APZ42_020791	EOG090X09ZA	A0A164XEN7	A0A0P5G1N1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Protein MEMO1.	0.798
APZ42_020986	EOG090X09ZA	A0A164WVL9	A0A0P5G1N1	AMMECR1 protein.	Protein MEMO1.	0.710
APZ42_024857	APZ42_002734	A0A164TND3	A0A164I2R4	Receptor protein-tyrosine kinase.	Pro-neuregulin-2, membrane-bound.	0.969
APZ42_024857	APZ42_004669	A0A164TND3	A0A164GWT3	Receptor protein-tyrosine kinase.	Ras GTP-binding protein Rho1.	0.762
APZ42_024857	APZ42_012615	A0A164TND3	A0A0P5KP21	Receptor protein-tyrosine kinase.	Rho-related GTP-binding protein RhoF.	0.762
APZ42_024857	APZ42_032195	A0A164TND3	A0A164M896	Receptor protein-tyrosine kinase.	Pro-neuregulin-2, membrane-bound-like protein.	0.969
APZ42_024857	EOG090X09ZA	A0A164TND3	A0A0P5G1N1	Receptor protein-tyrosine kinase.	Protein MEMO1.	0.728

page 1 of 2

Network Stats

number of nodes:

5

number of edges:

5

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

4

PPI enrichment p-value:

0.375

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000169

Regulation of peptidyl-cysteine S-nitrosylation

2 of 4

3.16

1.37

0.0125

GO:0098974

Postsynaptic actin cytoskeleton organization

2 of 7

2.92

1.31

0.0150

GO:0042730

Fibrinolysis

2 of 9

2.81

1.31

0.0150

GO:0060307

Regulation of ventricular cardiac muscle cell membrane repolarization

2 of 11

2.73

1.3

0.0150

GO:1901385

Regulation of voltage-gated calcium channel activity

2 of 21

2.44

1.12

0.0264

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050998

Nitric-oxide synthase binding

2 of 9

2.81

1.34

0.0134

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0002102

Podosome

2 of 13

2.65

1.35

0.0127

GO:0033017

Sarcoplasmic reticulum membrane

2 of 18

2.51

1.34

0.0127

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:32351978

(2020) Erysipelothrix Spp.: Past, Present, and Future Directions in Vaccine Research.

2 of 3

3.29

2.04

0.0015

PMID:38254464

(2024) Pathogenic Potential of Coagulase-Positive Staphylococcus Strains Isolated from Aviary Capercaillies and Free-Living Birds in Southeastern Poland.

2 of 4

3.16

2.03

0.0015

PMID:31078554

(2019) How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts.

2 of 9

2.81

1.83

0.0027

PMID:22229971

(2012) Biology and pathogenesis of Acanthamoeba.

2 of 10

2.77

1.83

0.0027

PMID:37889324

(2023) Gallibacterium anatis infection in poultry: a comprehensive review.

2 of 13

2.65

1.77

0.0031

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26252

Mixed, incl. Regulation of peptidyl-cysteine S-nitrosylation, and PKHG1/2/3, pleckstrin homology (PH) domain

3 of 6

3.16

3.77

5.32e-06

CL:19214

Mixed, incl. Fibrinolysis, and Fibrinogen

2 of 12

2.69

1.65

0.0047

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8964041

LDL remodeling

2 of 9

2.81

1.48

0.0085

MAP-8963899

Plasma lipoprotein remodeling

2 of 29

2.3

1.01

0.0360

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000562

Heart

2 of 217

1.43

0.94

0.0195

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005577

Fibrinogen complex

2 of 8

2.86

1.58

0.0062

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0797

Tissue remodeling

2 of 2

3.47

2.7

0.00018

KW-0280

Fibrinolysis

2 of 2

3.47

2.7

0.00018

KW-0420

Kringle

2 of 14

2.62

2.21

0.00071

KW-0720

Serine protease

2 of 43

2.13

1.55

0.0049

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023317

Peptidase S1A, plasmin

2 of 2

3.47

1.8

0.0033

IPR003609

PAN/Apple domain

2 of 4

3.16

1.72

0.0041

IPR038178

Kringle superfamily

2 of 14

2.62

1.23

0.0190

IPR018056

Kringle, conserved site

2 of 13

2.65

1.23

0.0190

IPR000001

Kringle

2 of 14

2.62

1.23

0.0190

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

2 of 14

2.62

1.49

0.0079

SM00462

Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain

2 of 26

2.35

1.33

0.0123

SM00020

Trypsin-like serine protease

2 of 63

1.97

0.91

0.0451

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