APZ42_012358 protein (Daphnia magna) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

APZ42_012358

ATP-binding cassette sub-family F member 2. (614 aa)

Predicted Functional Partners:

APZ42_020212

0.971

APZ42_024522

0.890

APZ42_031373

0.881

APZ42_028773

0.879

APZ42_013323

0.878

APZ42_028276

0.875

APZ42_025965

0.873

APZ42_015976

0.871

EOG090X0IGM

0.871

EOG090X09YS

0.870

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_012358	APZ42_013323	A0A0P6G7N3	A0A162QW62	ATP-binding cassette sub-family F member 2.	39S ribosomal protein L21, mitochondrial.	0.878
APZ42_012358	APZ42_015976	A0A0P6G7N3	A0A0P5TCQ6	ATP-binding cassette sub-family F member 2.	60S ribosomal protein L17; Belongs to the universal ribosomal protein uL22 family.	0.871
APZ42_012358	APZ42_020212	A0A0P6G7N3	A0A162CEJ2	ATP-binding cassette sub-family F member 2.	ATP-binding cassette sub-family E member 1.	0.971
APZ42_012358	APZ42_024522	A0A0P6G7N3	A0A164TX28	ATP-binding cassette sub-family F member 2.	39S ribosomal protein L27, mitochondrial.	0.890
APZ42_012358	APZ42_025965	A0A0P6G7N3	A0A0P5VF79	ATP-binding cassette sub-family F member 2.	60S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.	0.873
APZ42_012358	APZ42_028276	A0A0P6G7N3	A0A0P5KPE5	ATP-binding cassette sub-family F member 2.	60S ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.875
APZ42_012358	APZ42_028773	A0A0P6G7N3	A0A162D6P6	ATP-binding cassette sub-family F member 2.	60S ribosomal protein L35.	0.879
APZ42_012358	APZ42_031373	A0A0P6G7N3	A0A164MWP8	ATP-binding cassette sub-family F member 2.	Eukaryotic translation initiation factor 5B.	0.881
APZ42_012358	EOG090X09YS	A0A0P6G7N3	A0A0P4Y7K1	ATP-binding cassette sub-family F member 2.	60S ribosomal protein L5.	0.870
APZ42_012358	EOG090X0IGM	A0A0P6G7N3	A0A0P5YTD8	ATP-binding cassette sub-family F member 2.	39S ribosomal protein L32, mitochondrial.	0.871
APZ42_013323	APZ42_012358	A0A162QW62	A0A0P6G7N3	39S ribosomal protein L21, mitochondrial.	ATP-binding cassette sub-family F member 2.	0.878
APZ42_013323	APZ42_015976	A0A162QW62	A0A0P5TCQ6	39S ribosomal protein L21, mitochondrial.	60S ribosomal protein L17; Belongs to the universal ribosomal protein uL22 family.	0.999
APZ42_013323	APZ42_024522	A0A162QW62	A0A164TX28	39S ribosomal protein L21, mitochondrial.	39S ribosomal protein L27, mitochondrial.	0.999
APZ42_013323	APZ42_025965	A0A162QW62	A0A0P5VF79	39S ribosomal protein L21, mitochondrial.	60S ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family.	0.999
APZ42_013323	APZ42_028276	A0A162QW62	A0A0P5KPE5	39S ribosomal protein L21, mitochondrial.	60S ribosomal protein L23a; Belongs to the universal ribosomal protein uL23 family.	0.999
APZ42_013323	APZ42_028773	A0A162QW62	A0A162D6P6	39S ribosomal protein L21, mitochondrial.	60S ribosomal protein L35.	0.999
APZ42_013323	APZ42_031373	A0A162QW62	A0A164MWP8	39S ribosomal protein L21, mitochondrial.	Eukaryotic translation initiation factor 5B.	0.893
APZ42_013323	EOG090X09YS	A0A162QW62	A0A0P4Y7K1	39S ribosomal protein L21, mitochondrial.	60S ribosomal protein L5.	0.999
APZ42_013323	EOG090X0IGM	A0A162QW62	A0A0P5YTD8	39S ribosomal protein L21, mitochondrial.	39S ribosomal protein L32, mitochondrial.	0.999
APZ42_015976	APZ42_012358	A0A0P5TCQ6	A0A0P6G7N3	60S ribosomal protein L17; Belongs to the universal ribosomal protein uL22 family.	ATP-binding cassette sub-family F member 2.	0.871

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.806

expected number of edges:

28

PPI enrichment p-value:

0.00127

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 104

1.54

3.31

2.45e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 53

1.79

4.48

8.78e-15

GO:0019843

rRNA binding

7 of 42

1.73

3.12

3.68e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.51

1.2

0.0063

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

11 of 61

1.77

4.86

1.07e-17

GO:0044391

Ribosomal subunit

2 of 13

1.7

0.92

0.0141

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33351813

(2020) Complete genome reveals genetic repertoire and potential metabolic strategies involved in lignin degradation by environmental ligninolytic Klebsiella variicola P1CD1.

6 of 29

1.83

3.22

9.46e-09

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:188

Ribosome

11 of 17

2.32

8.92

5.53e-22

CL:191

Ribosome

8 of 12

2.34

6.71

2.06e-15

CL:193

Small ribosomal subunit, and Ribosome

3 of 5

2.29

2.23

5.14e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gfo03010

Ribosome

11 of 53

1.83

5.3

2.53e-18

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

6 of 37

1.72

2.61

2.61e-07

GOCC:0043232

Intracellular non-membrane-bounded organelle

7 of 125

1.26

1.58

1.62e-06

GOCC:0043229

Intracellular organelle

10 of 380

0.93

1.04

2.92e-07

GOCC:0005622

Intracellular

11 of 1204

0.47

0.4

0.00031

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 56

1.81

5.09

8.08e-18

KW-0699

rRNA-binding

7 of 38

1.78

3.42

6.31e-10

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