APZ42_003269 protein (Daphnia magna) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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APZ42_003269

ABC transmembrane type-1 domain-containing protein. (197 aa)

Predicted Functional Partners:

APZ42_012084

0.644

APZ42_012087

0.644

APZ42_022906

0.622

APZ42_016450

0.616

APZ42_024490

0.616

APZ42_029329

0.616

APZ42_003320

0.616

APZ42_033871

0.608

APZ42_028069

0.607

APZ42_003369

0.605

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_003269	APZ42_003320	A0A162C322	A0A164HMA9	ABC transmembrane type-1 domain-containing protein.	Putative Huntingtin-interacting protein 1.	0.616
APZ42_003269	APZ42_003369	A0A162C322	A0A164HKW3	ABC transmembrane type-1 domain-containing protein.	ANK_REP_REGION domain-containing protein.	0.605
APZ42_003269	APZ42_012084	A0A162C322	A0A162S3B1	ABC transmembrane type-1 domain-containing protein.	Acetyl-CoA carboxylase.	0.644
APZ42_003269	APZ42_012087	A0A162C322	A0A162S3C6	ABC transmembrane type-1 domain-containing protein.	Acetyl-CoA carboxylase.	0.644
APZ42_003269	APZ42_016450	A0A162C322	A0A0P4YEW1	ABC transmembrane type-1 domain-containing protein.	Putative Transcription initiation factor TFIID subunit 4.	0.616
APZ42_003269	APZ42_022906	A0A162C322	A0A0P5ZUN0	ABC transmembrane type-1 domain-containing protein.	Inositol 1,4,5-trisphosphate receptor type.	0.622
APZ42_003269	APZ42_024490	A0A162C322	A0A0P5ZI16	ABC transmembrane type-1 domain-containing protein.	Cytochrome b-c1 complex subunit 2, mitochondrial.	0.616
APZ42_003269	APZ42_028069	A0A162C322	A0A0P5M1A9	ABC transmembrane type-1 domain-containing protein.	26S proteasome regulatory complex subunit p48B; Belongs to the AAA ATPase family.	0.607
APZ42_003269	APZ42_029329	A0A162C322	A0A162D572	ABC transmembrane type-1 domain-containing protein.	Putative Huntingtin interacting protein 1.	0.616
APZ42_003269	APZ42_033871	A0A162C322	A0A164KNT3	ABC transmembrane type-1 domain-containing protein.	Leucine-rich repeat kinase.	0.608
APZ42_003320	APZ42_003269	A0A164HMA9	A0A162C322	Putative Huntingtin-interacting protein 1.	ABC transmembrane type-1 domain-containing protein.	0.616
APZ42_003320	APZ42_029329	A0A164HMA9	A0A162D572	Putative Huntingtin-interacting protein 1.	Putative Huntingtin interacting protein 1.	0.933
APZ42_003369	APZ42_003269	A0A164HKW3	A0A162C322	ANK_REP_REGION domain-containing protein.	ABC transmembrane type-1 domain-containing protein.	0.605
APZ42_003369	APZ42_022906	A0A164HKW3	A0A0P5ZUN0	ANK_REP_REGION domain-containing protein.	Inositol 1,4,5-trisphosphate receptor type.	0.541
APZ42_003369	APZ42_028069	A0A164HKW3	A0A0P5M1A9	ANK_REP_REGION domain-containing protein.	26S proteasome regulatory complex subunit p48B; Belongs to the AAA ATPase family.	0.450
APZ42_003369	APZ42_033871	A0A164HKW3	A0A164KNT3	ANK_REP_REGION domain-containing protein.	Leucine-rich repeat kinase.	0.931
APZ42_012084	APZ42_003269	A0A162S3B1	A0A162C322	Acetyl-CoA carboxylase.	ABC transmembrane type-1 domain-containing protein.	0.644
APZ42_012084	APZ42_012087	A0A162S3B1	A0A162S3C6	Acetyl-CoA carboxylase.	Acetyl-CoA carboxylase.	0.900
APZ42_012084	APZ42_024490	A0A162S3B1	A0A0P5ZI16	Acetyl-CoA carboxylase.	Cytochrome b-c1 complex subunit 2, mitochondrial.	0.578
APZ42_012087	APZ42_003269	A0A162S3C6	A0A162C322	Acetyl-CoA carboxylase.	ABC transmembrane type-1 domain-containing protein.	0.644

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.804

expected number of edges:

12

PPI enrichment p-value:

2.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

7 of 82

2.53

6.47

8.42e-14

GO:0019682

glyceraldehyde-3-phosphate metabolic process

4 of 8

3.3

5.04

6.78e-10

GO:0005975

Carbohydrate metabolic process

8 of 308

2.01

4.78

1.67e-12

GO:0006096

Glycolytic process

4 of 21

2.88

4.28

1.14e-08

GO:0019637

Organophosphate metabolic process

10 of 677

1.77

4.26

4.29e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

5 of 211

1.97

2.62

2.42e-06

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

4 of 144

2.04

2.25

2.58e-05

GO:0052591

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

2 of 2

3.6

2.11

0.00016

GO:0008929

Methylglyoxal synthase activity

2 of 2

3.6

2.11

0.00016

GO:0004807

Triose-phosphate isomerase activity

2 of 2

3.6

2.11

0.00016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.7

2.12e-07

GO:0005829

Cytosol

7 of 1756

1.2

1.32

2.25e-05

GO:0005739

Mitochondrion

4 of 1201

1.12

0.64

0.0243

GO:0005737

Cytoplasm

11 of 10623

0.61

0.54

5.51e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:9211740

(1997) An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks.

2 of 2

3.6

1.5

0.0020

PMID:35193395

(2022) Novel protein from larval sponge cells, ilborin, is related to energy turnover and calcium binding and is conserved among marine invertebrates.

2 of 3

3.42

1.5

0.0020

PMID:34769888

(2021) Prevalence, Molecular Characterization and Antimicrobial Susceptibility of Clostridioides difficile Isolated from Pig Carcasses and Pork Products in Central Italy.

2 of 2

3.6

1.5

0.0020

PMID:34093163

(2021) Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm.

2 of 2

3.6

1.5

0.0020

PMID:31547548

(2019) Enzymes from Marine Polar Regions and Their Biotechnological Applications.

2 of 4

3.3

1.5

0.0020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11044

Glycolysis, and Transketolase or transaldolase activity

5 of 12

3.22

6.02

9.38e-12

CL:11045

Glycolysis, and Phosphopyruvate hydratase complex

4 of 7

3.35

5.02

7.76e-10

CL:3319

Glycerol catabolic process, and Ethanolamine metabolic process

3 of 6

3.3

3.52

4.29e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu00051

Fructose and mannose metabolism

5 of 22

2.95

6.14

3.52e-12

aqu01200

Carbon metabolism

6 of 106

2.35

5.35

7.15e-12

aqu01230

Biosynthesis of amino acids

5 of 57

2.54

5.11

9.37e-11

aqu00010

Glycolysis / Gluconeogenesis

4 of 38

2.62

4.26

7.56e-09

aqu00030

Pentose phosphate pathway

3 of 22

2.73

3.32

6.76e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 20

2.9

4.29

1.16e-08

MAP-1483166

Synthesis of PA

4 of 29

2.74

4.08

2.23e-08

MAP-70263

Gluconeogenesis

4 of 55

2.46

3.48

1.98e-07

MAP-71387

Metabolism of carbohydrates

6 of 287

1.92

3.35

1.32e-08

MAP-70326

Glucose metabolism

4 of 65

2.39

3.34

3.13e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.81

1.34e-07

GOCC:0005737

Cytoplasm

11 of 5405

0.91

1.01

1.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

4 of 12

3.12

4.91

1.03e-09

KW-0312

Gluconeogenesis

2 of 3

3.42

2.29

7.46e-05

KW-0704

Schiff base

2 of 5

3.2

2.21

0.00010

KW-0456

Lyase

2 of 47

2.23

1.26

0.0044

KW-0413

Isomerase

2 of 57

2.14

1.21

0.0051

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00274

Fructose-bisphosphate aldolase class-I

2 of 2

3.6

1.79

0.00060

PF00121

Triosephosphate isomerase

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 58

2.44

2.76

5.64e-06

IPR035990

Triosephosphate isomerase superfamily

2 of 2

3.6

1.72

0.00080

IPR029768

Fructose-bisphosphate aldolase class-I active site

2 of 2

3.6

1.72

0.00080

IPR000741

Fructose-bisphosphate aldolase, class-I

2 of 2

3.6

1.72

0.00080

IPR000652

Triosephosphate isomerase

2 of 2

3.6

1.72

0.00080

(more ...)

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