APZ42_019750 protein (Daphnia magna) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:

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Score

APZ42_019750

Transport Sec24B,-like protein. (400 aa)

Predicted Functional Partners:

APZ42_030563

0.991

EOG090X07N7

0.990

APZ42_033286

0.980

APZ42_019396

0.979

APZ42_011545

0.964

EOG090X0HBC

0.961

APZ42_023261

0.932

APZ42_004973

0.921

APZ42_027629

0.809

APZ42_018667

0.780

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_004973	APZ42_011545	A0A0P6ET81	A0A162SSN7	Ankyrin repeat domain-containing protein 40.	Protein transport Sec16A-like protein.	0.928
APZ42_004973	APZ42_018667	A0A0P6ET81	A0A0P6A860	Ankyrin repeat domain-containing protein 40.	Syntaxin-5; Belongs to the syntaxin family.	0.768
APZ42_004973	APZ42_019750	A0A0P6ET81	A0A162CM36	Ankyrin repeat domain-containing protein 40.	Transport Sec24B,-like protein.	0.921
APZ42_004973	APZ42_023261	A0A0P6ET81	A0A164V2T5	Ankyrin repeat domain-containing protein 40.	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family.	0.977
APZ42_004973	APZ42_030563	A0A0P6ET81	A0A0P5E3T1	Ankyrin repeat domain-containing protein 40.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.987
APZ42_004973	APZ42_033286	A0A0P6ET81	A0A164L8C2	Ankyrin repeat domain-containing protein 40.	Protein transport protein Sec24C.	0.920
APZ42_004973	EOG090X07N7	A0A0P6ET81	A0A162DGD4	Ankyrin repeat domain-containing protein 40.	SEC13 protein; Belongs to the WD repeat SEC13 family.	0.986
APZ42_004973	EOG090X0HBC	A0A0P6ET81	A0A162SSQ9	Ankyrin repeat domain-containing protein 40.	EOG090X0HBC; Belongs to the synaptobrevin family.	0.820
APZ42_011545	APZ42_004973	A0A162SSN7	A0A0P6ET81	Protein transport Sec16A-like protein.	Ankyrin repeat domain-containing protein 40.	0.928
APZ42_011545	APZ42_018667	A0A162SSN7	A0A0P6A860	Protein transport Sec16A-like protein.	Syntaxin-5; Belongs to the syntaxin family.	0.839
APZ42_011545	APZ42_019396	A0A162SSN7	A0A0P5ZWL8	Protein transport Sec16A-like protein.	Transport protein Sec31A.	0.953
APZ42_011545	APZ42_019750	A0A162SSN7	A0A162CM36	Protein transport Sec16A-like protein.	Transport Sec24B,-like protein.	0.964
APZ42_011545	APZ42_023261	A0A162SSN7	A0A164V2T5	Protein transport Sec16A-like protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. SAR1 family.	0.938
APZ42_011545	APZ42_030563	A0A162SSN7	A0A0P5E3T1	Protein transport Sec16A-like protein.	Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily.	0.993
APZ42_011545	APZ42_033286	A0A162SSN7	A0A164L8C2	Protein transport Sec16A-like protein.	Protein transport protein Sec24C.	0.990
APZ42_011545	EOG090X07N7	A0A162SSN7	A0A162DGD4	Protein transport Sec16A-like protein.	SEC13 protein; Belongs to the WD repeat SEC13 family.	0.997
APZ42_011545	EOG090X0HBC	A0A162SSN7	A0A162SSQ9	Protein transport Sec16A-like protein.	EOG090X0HBC; Belongs to the synaptobrevin family.	0.836
APZ42_018667	APZ42_004973	A0A0P6A860	A0A0P6ET81	Syntaxin-5; Belongs to the syntaxin family.	Ankyrin repeat domain-containing protein 40.	0.768
APZ42_018667	APZ42_011545	A0A0P6A860	A0A162SSN7	Syntaxin-5; Belongs to the syntaxin family.	Protein transport Sec16A-like protein.	0.839
APZ42_018667	APZ42_019396	A0A0P6A860	A0A0P5ZWL8	Syntaxin-5; Belongs to the syntaxin family.	Transport protein Sec31A.	0.830

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

37

average node degree:

6.73

avg. local clustering coefficient:

0.804

expected number of edges:

12

PPI enrichment p-value:

2.46e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016052

Carbohydrate catabolic process

7 of 82

2.53

6.47

8.42e-14

GO:0019682

glyceraldehyde-3-phosphate metabolic process

4 of 8

3.3

5.04

6.78e-10

GO:0005975

Carbohydrate metabolic process

8 of 308

2.01

4.78

1.67e-12

GO:0006096

Glycolytic process

4 of 21

2.88

4.28

1.14e-08

GO:0019637

Organophosphate metabolic process

10 of 677

1.77

4.26

4.29e-14

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016829

Lyase activity

5 of 211

1.97

2.62

2.42e-06

GO:0016614

Oxidoreductase activity, acting on CH-OH group of donors

4 of 144

2.04

2.25

2.58e-05

GO:0052591

sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity

2 of 2

3.6

2.11

0.00016

GO:0008929

Methylglyoxal synthase activity

2 of 2

3.6

2.11

0.00016

GO:0004807

Triose-phosphate isomerase activity

2 of 2

3.6

2.11

0.00016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.7

2.12e-07

GO:0005829

Cytosol

7 of 1756

1.2

1.32

2.25e-05

GO:0005739

Mitochondrion

4 of 1201

1.12

0.64

0.0243

GO:0005737

Cytoplasm

11 of 10623

0.61

0.54

5.51e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:9211740

(1997) An estimate of divergence time of Parazoa and Eumetazoa and that of Cephalochordata and Vertebrata by aldolase and triose phosphate isomerase clocks.

2 of 2

3.6

1.5

0.0020

PMID:35193395

(2022) Novel protein from larval sponge cells, ilborin, is related to energy turnover and calcium binding and is conserved among marine invertebrates.

2 of 3

3.42

1.5

0.0020

PMID:34769888

(2021) Prevalence, Molecular Characterization and Antimicrobial Susceptibility of Clostridioides difficile Isolated from Pig Carcasses and Pork Products in Central Italy.

2 of 2

3.6

1.5

0.0020

PMID:34093163

(2021) Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm.

2 of 2

3.6

1.5

0.0020

PMID:31547548

(2019) Enzymes from Marine Polar Regions and Their Biotechnological Applications.

2 of 4

3.3

1.5

0.0020

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11044

Glycolysis, and Transketolase or transaldolase activity

5 of 12

3.22

6.02

9.38e-12

CL:11045

Glycolysis, and Phosphopyruvate hydratase complex

4 of 7

3.35

5.02

7.76e-10

CL:3319

Glycerol catabolic process, and Ethanolamine metabolic process

3 of 6

3.3

3.52

4.29e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu00051

Fructose and mannose metabolism

5 of 22

2.95

6.14

3.52e-12

aqu01200

Carbon metabolism

6 of 106

2.35

5.35

7.15e-12

aqu01230

Biosynthesis of amino acids

5 of 57

2.54

5.11

9.37e-11

aqu00010

Glycolysis / Gluconeogenesis

4 of 38

2.62

4.26

7.56e-09

aqu00030

Pentose phosphate pathway

3 of 22

2.73

3.32

6.76e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 20

2.9

4.29

1.16e-08

MAP-1483166

Synthesis of PA

4 of 29

2.74

4.08

2.23e-08

MAP-70263

Gluconeogenesis

4 of 55

2.46

3.48

1.98e-07

MAP-71387

Metabolism of carbohydrates

6 of 287

1.92

3.35

1.32e-08

MAP-70326

Glucose metabolism

4 of 65

2.39

3.34

3.13e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009331

glycerol-3-phosphate dehydrogenase complex

3 of 3

3.6

3.81

1.34e-07

GOCC:0005737

Cytoplasm

11 of 5405

0.91

1.01

1.25e-07

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

4 of 12

3.12

4.91

1.03e-09

KW-0312

Gluconeogenesis

2 of 3

3.42

2.29

7.46e-05

KW-0704

Schiff base

2 of 5

3.2

2.21

0.00010

KW-0456

Lyase

2 of 47

2.23

1.26

0.0044

KW-0413

Isomerase

2 of 57

2.14

1.21

0.0051

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00274

Fructose-bisphosphate aldolase class-I

2 of 2

3.6

1.79

0.00060

PF00121

Triosephosphate isomerase

2 of 2

3.6

1.79

0.00060

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013785

Aldolase-type TIM barrel

4 of 58

2.44

2.76

5.64e-06

IPR035990

Triosephosphate isomerase superfamily

2 of 2

3.6

1.72

0.00080

IPR029768

Fructose-bisphosphate aldolase class-I active site

2 of 2

3.6

1.72

0.00080

IPR000741

Fructose-bisphosphate aldolase, class-I

2 of 2

3.6

1.72

0.00080

IPR000652

Triosephosphate isomerase

2 of 2

3.6

1.72

0.00080

(more ...)

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