APZ42_014954 protein (Daphnia magna) - STRING interaction network

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

APZ42_014954

Argininosuccinate synthase. (408 aa)

Predicted Functional Partners:

APZ42_014766

0.999

APZ42_014909

0.998

APZ42_002241

0.995

APZ42_030973

0.990

APZ42_011795

0.980

APZ42_020928

0.978

APZ42_034435

0.974

APZ42_012180

0.958

APZ42_016345

0.957

APZ42_013400

0.917

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002241	APZ42_011795	A0A164IEM5	A0A162T0I9	Ornithine carbamoyltransferase, mitochondrial-like protein.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.939
APZ42_002241	APZ42_014766	A0A164IEM5	A0A162PLA6	Ornithine carbamoyltransferase, mitochondrial-like protein.	Argininosuccinate lyase.	0.857
APZ42_002241	APZ42_014909	A0A164IEM5	A0A162P1A7	Ornithine carbamoyltransferase, mitochondrial-like protein.	CAD protein.	0.986
APZ42_002241	APZ42_014954	A0A164IEM5	A0A162P1R3	Ornithine carbamoyltransferase, mitochondrial-like protein.	Argininosuccinate synthase.	0.995
APZ42_002241	APZ42_020928	A0A164IEM5	A0A164X449	Ornithine carbamoyltransferase, mitochondrial-like protein.	Mutant tan.	0.928
APZ42_002241	APZ42_030973	A0A164IEM5	A0A164N8Q0	Ornithine carbamoyltransferase, mitochondrial-like protein.	Class B secretin G-protein-coupled receptor gproca3.	0.938
APZ42_011795	APZ42_002241	A0A162T0I9	A0A164IEM5	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Ornithine carbamoyltransferase, mitochondrial-like protein.	0.939
APZ42_011795	APZ42_012180	A0A162T0I9	A0A162S7K9	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aspartate aminotransferase.	0.429
APZ42_011795	APZ42_014766	A0A162T0I9	A0A162PLA6	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Argininosuccinate lyase.	0.993
APZ42_011795	APZ42_014909	A0A162T0I9	A0A162P1A7	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	CAD protein.	0.796
APZ42_011795	APZ42_014954	A0A162T0I9	A0A162P1R3	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Argininosuccinate synthase.	0.980
APZ42_011795	APZ42_016345	A0A162T0I9	A0A0P5G423	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Aspartate aminotransferase.	0.451
APZ42_011795	APZ42_030973	A0A162T0I9	A0A164N8Q0	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Class B secretin G-protein-coupled receptor gproca3.	0.796
APZ42_011795	APZ42_034435	A0A162T0I9	A0A0P5GEF2	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.656
APZ42_012180	APZ42_011795	A0A162S7K9	A0A162T0I9	Aspartate aminotransferase.	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.429
APZ42_012180	APZ42_014766	A0A162S7K9	A0A162PLA6	Aspartate aminotransferase.	Argininosuccinate lyase.	0.753
APZ42_012180	APZ42_014909	A0A162S7K9	A0A162P1A7	Aspartate aminotransferase.	CAD protein.	0.941
APZ42_012180	APZ42_014954	A0A162S7K9	A0A162P1R3	Aspartate aminotransferase.	Argininosuccinate synthase.	0.958
APZ42_012180	APZ42_016345	A0A162S7K9	A0A0P5G423	Aspartate aminotransferase.	Aspartate aminotransferase.	0.991
APZ42_012180	APZ42_020928	A0A162S7K9	A0A164X449	Aspartate aminotransferase.	Mutant tan.	0.429

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070006

Metalloaminopeptidase activity

4 of 9

2.41

2.88

3.04e-06

GO:0030145

Manganese ion binding

3 of 9

2.29

2.03

0.00013

GO:0046914

Transition metal ion binding

5 of 110

1.42

1.46

0.00013

GO:0046872

Metal ion binding

8 of 627

0.87

0.8

0.00013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005965

Protein farnesyltransferase complex

2 of 3

2.59

1.03

0.0132

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8231

Mixed, incl. Pyrimidine nucleotide-sugar transmembrane transport, and Macromolecule depalmitoylation

6 of 35

2.0

3.43

2.02e-08

CL:8236

Pyrimidine nucleotide-sugar transmembrane transport, and Aminopeptidase activity

5 of 21

2.14

3.34

1.05e-07

CL:6054

Terpenoid backbone biosynthesis, and Short chain dehydrogenase

4 of 22

2.02

2.37

1.31e-05

CL:8258

Pyrimidine nucleotide-sugar transmembrane transport, and Aminopeptidase P, N-terminal

3 of 10

2.24

1.96

0.00017

CL:8260

Nucleotide-sugar transporter, and Aminopeptidase P, N-terminal

2 of 5

2.37

1.18

0.0066

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

4 of 20

2.06

2.55

5.82e-06

map00260

Glycine, serine and threonine metabolism

4 of 20

2.06

2.55

5.82e-06

map01100

Metabolic pathways

8 of 959

0.68

0.55

0.0011

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005965

Protein farnesyltransferase complex

2 of 3

2.59

0.99

0.0156

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0464

Manganese

3 of 12

2.16

1.81

0.00031

KW-0031

Aminopeptidase

2 of 11

2.02

0.93

0.0172

KW-0479

Metal-binding

5 of 353

0.91

0.58

0.0172

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00557

Metallopeptidase family M24

4 of 10

2.37

2.81

3.81e-06

PF00432

Prenyltransferase and squalene oxidase repeat

2 of 3

2.59

1.08

0.0108

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029149

Creatinase/Aminopeptidase P/Spt16, N-terminal

4 of 5

2.67

3.13

1.48e-06

IPR036005

Creatinase/aminopeptidase-like

4 of 10

2.37

2.72

5.86e-06

IPR000994

Peptidase M24

4 of 10

2.37

2.72

5.86e-06

IPR007865

Aminopeptidase P, N-terminal

3 of 3

2.76

2.36

4.70e-05

IPR045089

Prenyltransferase subunit beta

2 of 3

2.59

1.03

0.0133

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01011

Aminopeptidase P, N-terminal domain

3 of 3

2.76

2.55

2.05e-05

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