APZ42_009605 protein (Daphnia magna) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Gene Fusion

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[Homology]

Score

APZ42_009605

Uncharacterized protein. (115 aa)

Predicted Functional Partners:

APZ42_031912

0.797

APZ42_010980

0.574

APZ42_031506

0.569

APZ42_011612

0.561

APZ42_017650

0.560

APZ42_025541

0.557

APZ42_024857

0.553

APZ42_030620

0.520

APZ42_011418

0.518

APZ42_002734

0.470

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002734	APZ42_009605	A0A164I2R4	A0A164DX08	Pro-neuregulin-2, membrane-bound.	Uncharacterized protein.	0.470
APZ42_002734	APZ42_024857	A0A164I2R4	A0A164TND3	Pro-neuregulin-2, membrane-bound.	Receptor protein-tyrosine kinase.	0.969
APZ42_009605	APZ42_002734	A0A164DX08	A0A164I2R4	Uncharacterized protein.	Pro-neuregulin-2, membrane-bound.	0.470
APZ42_009605	APZ42_010980	A0A164DX08	A0A162TD12	Uncharacterized protein.	Protein lin-52.	0.574
APZ42_009605	APZ42_011418	A0A164DX08	A0A0P5F3S8	Uncharacterized protein.	Replication protein A 32 kDa subunit.	0.518
APZ42_009605	APZ42_011612	A0A164DX08	A0A162SUI1	Uncharacterized protein.	Putative Myb-related protein B.	0.561
APZ42_009605	APZ42_017650	A0A164DX08	A0A0P5V197	Uncharacterized protein.	Histone-binding protein RBBP4.	0.560
APZ42_009605	APZ42_024857	A0A164DX08	A0A164TND3	Uncharacterized protein.	Receptor protein-tyrosine kinase.	0.553
APZ42_009605	APZ42_025541	A0A164DX08	A0A164SYA7	Uncharacterized protein.	Protein lin-9.	0.557
APZ42_009605	APZ42_030620	A0A164DX08	A0A164NPL0	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.520
APZ42_009605	APZ42_031506	A0A164DX08	A0A0P5T8R7	Uncharacterized protein.	Lin-54.	0.569
APZ42_009605	APZ42_031912	A0A164DX08	A0A164ME63	Uncharacterized protein.	Putative ATP-dependent RNA helicase DHX58.	0.797
APZ42_010980	APZ42_009605	A0A162TD12	A0A164DX08	Protein lin-52.	Uncharacterized protein.	0.574
APZ42_010980	APZ42_011612	A0A162TD12	A0A162SUI1	Protein lin-52.	Putative Myb-related protein B.	0.991
APZ42_010980	APZ42_017650	A0A162TD12	A0A0P5V197	Protein lin-52.	Histone-binding protein RBBP4.	0.976
APZ42_010980	APZ42_025541	A0A162TD12	A0A164SYA7	Protein lin-52.	Protein lin-9.	0.999
APZ42_010980	APZ42_031506	A0A162TD12	A0A0P5T8R7	Protein lin-52.	Lin-54.	0.998
APZ42_011418	APZ42_009605	A0A0P5F3S8	A0A164DX08	Replication protein A 32 kDa subunit.	Uncharacterized protein.	0.518
APZ42_011418	APZ42_030620	A0A0P5F3S8	A0A164NPL0	Replication protein A 32 kDa subunit.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.999
APZ42_011418	APZ42_031912	A0A0P5F3S8	A0A164ME63	Replication protein A 32 kDa subunit.	Putative ATP-dependent RNA helicase DHX58.	0.999

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.781

expected number of edges:

11

PPI enrichment p-value:

0.00219

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009167

Purine ribonucleoside monophosphate metabolic process

5 of 11

1.93

2.86

4.00e-07

GO:0009150

Purine ribonucleotide metabolic process

8 of 49

1.49

2.33

2.79e-08

GO:0009165

Nucleotide biosynthetic process

8 of 60

1.4

2.12

2.79e-08

GO:0009132

Nucleoside diphosphate metabolic process

4 of 14

1.73

1.95

3.70e-05

GO:0046037

GMP metabolic process

3 of 5

2.05

1.92

0.00015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019205

Nucleobase-containing compound kinase activity

3 of 11

1.71

0.97

0.0112

GO:0004748

Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

2 of 2

2.27

0.93

0.0189

GO:0004385

Guanylate kinase activity

2 of 2

2.27

0.93

0.0189

GO:0106130

Purine phosphoribosyltransferase activity

2 of 4

1.97

0.91

0.0189

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

3 of 15

1.57

0.89

0.0144

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005971

Ribonucleoside-diphosphate reductase complex

2 of 2

2.27

0.98

0.0153

GO:0005737

Cytoplasm

10 of 713

0.42

0.31

0.0153

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:673

Mixed, incl. Purine nucleoside monophosphate metabolic process, and Ribonucleoside hydrolase-like

7 of 21

1.8

3.37

1.38e-09

CL:676

Purine nucleoside monophosphate metabolic process, and Ribonucleoside hydrolase-like

6 of 14

1.9

3.33

1.26e-08

CL:671

Mixed, incl. Nucleoside monophosphate metabolic process, and Pteridine-containing compound metabolic process

9 of 40

1.62

3.24

2.71e-11

CL:678

Purine nucleoside monophosphate biosynthetic process

2 of 6

1.8

0.69

0.0475

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

11 of 72

1.46

2.97

2.17e-14

map00240

Pyrimidine metabolism

3 of 43

1.12

0.55

0.0489

map01100

Metabolic pathways

11 of 614

0.53

0.46

8.76e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-168249

Innate Immune System

3 of 19

1.47

1.05

0.0042

MAP-168256

Immune System

3 of 24

1.37

1.0

0.0042

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005971

Ribonucleoside-diphosphate reductase complex

2 of 2

2.27

0.82

0.0314

GOCC:0005622

Intracellular

10 of 759

0.39

0.28

0.0362

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0328

Glycosyltransferase

3 of 11

1.71

1.08

0.0063

KW-0660

Purine salvage

2 of 3

2.1

0.9

0.0205

KW-0808

Transferase

6 of 223

0.7

0.43

0.0264

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029057

Phosphoribosyltransferase-like

3 of 10

1.75

0.81

0.0266

IPR000836

Phosphoribosyltransferase domain

3 of 10

1.75

0.81

0.0266

IPR008145

Guanylate kinase/L-type calcium channel beta subunit

2 of 2

2.27

0.74

0.0438

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00072

Guanylate kinase homologues.

2 of 2

2.27

1.04

0.0116

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