APZ42_002127 protein (Daphnia magna) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Cooccurrence

Coexpression

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Score

APZ42_002127

Mannitol_dh_C domain-containing protein. (148 aa)

Predicted Functional Partners:

APZ42_032739

0.838

APZ42_018618

0.797

APZ42_030783

0.797

APZ42_021401

0.773

APZ42_028987

0.753

APZ42_020644

0.724

APZ42_012675

0.715

APZ42_021242

0.715

APZ42_032304

0.699

APZ42_014885

0.699

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002127	APZ42_012675	A0A164IHL2	A0A162RK30	Mannitol_dh_C domain-containing protein.	Phosphotransferase.	0.715
APZ42_002127	APZ42_014885	A0A164IHL2	A0A0P6A1S4	Mannitol_dh_C domain-containing protein.	4-hydroxybutyrate Coenzyme A transferase.	0.699
APZ42_002127	APZ42_018618	A0A164IHL2	A0A162CPJ4	Mannitol_dh_C domain-containing protein.	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	0.797
APZ42_002127	APZ42_020644	A0A164IHL2	A0A162CC70	Mannitol_dh_C domain-containing protein.	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic.	0.724
APZ42_002127	APZ42_021242	A0A164IHL2	A0A164WUF0	Mannitol_dh_C domain-containing protein.	Phosphotransferase.	0.715
APZ42_002127	APZ42_021401	A0A164IHL2	A0A0P4XDP1	Mannitol_dh_C domain-containing protein.	2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily.	0.773
APZ42_002127	APZ42_028987	A0A164IHL2	A0A164Q068	Mannitol_dh_C domain-containing protein.	Malonyl-CoA-acyl carrier protein transacylase.	0.753
APZ42_002127	APZ42_030783	A0A164IHL2	A0A164NBZ1	Mannitol_dh_C domain-containing protein.	Hydroxysteroid dehydrogenase protein 2.	0.797
APZ42_002127	APZ42_032304	A0A164IHL2	A0A0P5DYP5	Mannitol_dh_C domain-containing protein.	Acyl-coenzyme A thioesterase 9, mitochondrial.	0.699
APZ42_002127	APZ42_032739	A0A164IHL2	A0A164LU31	Mannitol_dh_C domain-containing protein.	Sorbitol dehydrogenase.	0.838
APZ42_012675	APZ42_002127	A0A162RK30	A0A164IHL2	Phosphotransferase.	Mannitol_dh_C domain-containing protein.	0.715
APZ42_012675	APZ42_018618	A0A162RK30	A0A162CPJ4	Phosphotransferase.	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	0.538
APZ42_012675	APZ42_030783	A0A162RK30	A0A164NBZ1	Phosphotransferase.	Hydroxysteroid dehydrogenase protein 2.	0.538
APZ42_012675	APZ42_032739	A0A162RK30	A0A164LU31	Phosphotransferase.	Sorbitol dehydrogenase.	0.894
APZ42_014885	APZ42_002127	A0A0P6A1S4	A0A164IHL2	4-hydroxybutyrate Coenzyme A transferase.	Mannitol_dh_C domain-containing protein.	0.699
APZ42_014885	APZ42_018618	A0A0P6A1S4	A0A162CPJ4	4-hydroxybutyrate Coenzyme A transferase.	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	0.907
APZ42_014885	APZ42_020644	A0A0P6A1S4	A0A162CC70	4-hydroxybutyrate Coenzyme A transferase.	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic.	0.845
APZ42_014885	APZ42_030783	A0A0P6A1S4	A0A164NBZ1	4-hydroxybutyrate Coenzyme A transferase.	Hydroxysteroid dehydrogenase protein 2.	0.907
APZ42_014885	APZ42_032304	A0A0P6A1S4	A0A0P5DYP5	4-hydroxybutyrate Coenzyme A transferase.	Acyl-coenzyme A thioesterase 9, mitochondrial.	0.802
APZ42_018618	APZ42_002127	A0A162CPJ4	A0A164IHL2	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	Mannitol_dh_C domain-containing protein.	0.797

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Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.816

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2001240

Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

3 of 21

2.78

2.06

0.00017

GO:0039528

Cytoplasmic pattern recognition receptor signaling pathway in response to virus

2 of 14

2.78

1.09

0.0107

GO:0038061

NIK/NF-kappaB signaling

2 of 30

2.45

0.82

0.0316

GO:0061709

Reticulophagy

2 of 38

2.35

0.81

0.0336

GO:0002218

Activation of innate immune response

2 of 36

2.37

0.81

0.0336

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035438

cyclic-di-GMP binding

2 of 2

3.63

1.68

0.00095

GO:0061507

2,3-cyclic GMP-AMP binding

2 of 4

3.32

1.62

0.0012

GO:0015459

Potassium channel regulator activity

3 of 98

2.11

1.44

0.0017

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005793

Endoplasmic reticulum-Golgi intermediate compartment

4 of 144

2.07

2.18

4.23e-05

GO:0055037

Recycling endosome

3 of 298

1.63

0.98

0.0094

GO:0033116

Endoplasmic reticulum-Golgi intermediate compartment membrane

2 of 70

2.08

0.89

0.0217

GO:0000421

Autophagosome membrane

2 of 66

2.11

0.89

0.0217

GO:0030134

COPII-coated ER to Golgi transport vesicle

2 of 117

1.86

0.7

0.0465

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7052

Mixed, incl. PDPK1 family, and CISK, PX domain

4 of 10

3.23

4.29

1.56e-08

CL:28606

Mixed, incl. Fork head domain conserved site1, and Interferon regulatory factor

3 of 89

2.15

1.49

0.0014

CL:28620

Mixed, incl. cyclic-di-GMP binding, and Regulation of MyD88-dependent toll-like receptor signaling pathway

2 of 11

2.89

1.37

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04068

FoxO signaling pathway

4 of 477

1.55

1.36

0.00070

map04623

Cytosolic DNA-sensing pathway

2 of 96

1.94

0.85

0.0238

map04621

NOD-like receptor signaling pathway

3 of 745

1.23

0.61

0.0413

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3270619

IRF3-mediated induction of type I IFN

2 of 8

3.02

1.41

0.0028

MAP-3249367

STAT6-mediated induction of chemokines

2 of 12

2.85

1.41

0.0028

MAP-3134975

Regulation of innate immune responses to cytosolic DNA

2 of 17

2.7

1.34

0.0037

MAP-1834941

STING mediated induction of host immune responses

2 of 19

2.65

1.33

0.0037

MAP-2672351

Stimuli-sensing channels

4 of 394

1.63

1.19

0.0028

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF15009

Transmembrane protein 173

2 of 2

3.63

1.65

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047191

Stimulator of interferon genes protein, C-terminal

2 of 2

3.63

1.4

0.0031

IPR038623

Stimulator of interferon genes protein, C-terminal domain superfamily

2 of 2

3.63

1.4

0.0031

IPR037900

CISK, PX domain

2 of 2

3.63

1.4

0.0031

IPR029158

Stimulator of interferon genes protein

2 of 2

3.63

1.4

0.0031

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