APZ42_025668 protein (Daphnia magna) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

APZ42_025668

Putative Neurabin-1. (526 aa)

Predicted Functional Partners:

APZ42_026388

0.696

APZ42_022851

0.696

APZ42_013305

0.545

APZ42_011837

0.526

APZ42_012466

0.402

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_011837	APZ42_025668	A0A162SG23	A0A164SV83	Serine/threonine-protein kinase BRSK1.	Putative Neurabin-1.	0.526
APZ42_012466	APZ42_025668	A0A162RUN4	A0A164SV83	Uncharacterized protein.	Putative Neurabin-1.	0.402
APZ42_013305	APZ42_025668	A0A162QW26	A0A164SV83	Liprin-alpha.	Putative Neurabin-1.	0.545
APZ42_022851	APZ42_025668	A0A164VVM4	A0A164SV83	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Putative Neurabin-1.	0.696
APZ42_025668	APZ42_011837	A0A164SV83	A0A162SG23	Putative Neurabin-1.	Serine/threonine-protein kinase BRSK1.	0.526
APZ42_025668	APZ42_012466	A0A164SV83	A0A162RUN4	Putative Neurabin-1.	Uncharacterized protein.	0.402
APZ42_025668	APZ42_013305	A0A164SV83	A0A162QW26	Putative Neurabin-1.	Liprin-alpha.	0.545
APZ42_025668	APZ42_022851	A0A164SV83	A0A164VVM4	Putative Neurabin-1.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.696
APZ42_025668	APZ42_026388	A0A164SV83	A0A0P5T2B7	Putative Neurabin-1.	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	0.696
APZ42_026388	APZ42_025668	A0A0P5T2B7	A0A164SV83	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.	Putative Neurabin-1.	0.696

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.864

expected number of edges:

11

PPI enrichment p-value:

8.6e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006606

Protein import into nucleus

4 of 34

2.26

2.61

7.67e-06

GO:0006913

Nucleocytoplasmic transport

5 of 86

1.96

2.45

5.86e-06

GO:0031053

Primary miRNA processing

2 of 6

2.71

1.49

0.0019

GO:0051168

Nuclear export

3 of 52

1.95

1.47

0.0012

GO:0046907

Intracellular transport

6 of 440

1.33

1.41

7.16e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140142

Nucleocytoplasmic carrier activity

3 of 20

2.37

1.73

0.00057

GO:0000339

RNA cap binding

2 of 6

2.71

1.23

0.0057

GO:0061608

Nuclear import signal receptor activity

2 of 11

2.45

1.09

0.0101

GO:0008139

Nuclear localization sequence binding

2 of 10

2.49

1.09

0.0101

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 3

3.01

1.6

0.0013

GO:0005845

mRNA cap binding complex

2 of 3

3.01

1.6

0.0013

GO:0000808

Origin recognition complex

2 of 5

2.79

1.59

0.0013

GO:0005634

Nucleus

10 of 2571

0.78

0.72

4.14e-05

GO:0005694

Chromosome

3 of 263

1.25

0.6

0.0443

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4425

Nuclear localization sequence binding, and CAS/CSE protein, C-terminus

3 of 6

2.89

2.69

1.19e-05

CL:4287

Mixed, incl. Nuclear Envelope Breakdown, and Nucleocytoplasmic carrier activity

5 of 80

1.99

2.62

2.63e-06

CL:9082

mRNA cap binding complex, and Initiation factor 4G

2 of 5

2.79

1.36

0.0034

CL:6807

CDC6 association with the ORC:origin complex

2 of 6

2.71

1.33

0.0038

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

5 of 207

1.57

1.88

1.71e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68616

Assembly of the ORC complex at the origin of replication

3 of 16

2.46

2.03

0.00016

MAP-68867

Assembly of the pre-replicative complex

3 of 47

2.0

1.57

0.00081

MAP-68689

CDC6 association with the ORC:origin complex

2 of 7

2.65

1.44

0.0023

MAP-69278

Cell Cycle, Mitotic

5 of 316

1.39

1.3

0.00040

MAP-69002

DNA Replication Pre-Initiation

3 of 78

1.78

1.29

0.0023

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.01

1.34

0.0038

GOCC:0005664

Nuclear origin of replication recognition complex

2 of 5

2.79

1.32

0.0040

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0539

Nucleus

4 of 321

1.29

0.86

0.0084

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016024

Armadillo-type fold

4 of 238

1.42

0.64

0.0447

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00913

Importin-beta N-terminal domain

2 of 10

2.49

1.12

0.0090

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