APZ42_020109 protein (Daphnia magna) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

APZ42_020109

PKS_ER domain-containing protein. (342 aa)

Predicted Functional Partners:

APZ42_017098

0.886

APZ42_018618

0.796

APZ42_030783

0.796

APZ42_033871

0.671

APZ42_023861

0.666

APZ42_032739

0.661

APZ42_012675

0.654

APZ42_021242

0.654

APZ42_031583

0.639

APZ42_016748

0.638

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_012675	APZ42_018618	A0A162RK30	A0A162CPJ4	Phosphotransferase.	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	0.538
APZ42_012675	APZ42_020109	A0A162RK30	A0A164Y0Q5	Phosphotransferase.	PKS_ER domain-containing protein.	0.654
APZ42_012675	APZ42_030783	A0A162RK30	A0A164NBZ1	Phosphotransferase.	Hydroxysteroid dehydrogenase protein 2.	0.538
APZ42_012675	APZ42_031583	A0A162RK30	A0A164MQN5	Phosphotransferase.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.672
APZ42_012675	APZ42_032739	A0A162RK30	A0A164LU31	Phosphotransferase.	Sorbitol dehydrogenase.	0.894
APZ42_016748	APZ42_018618	A0A165A4L9	A0A162CPJ4	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	0.942
APZ42_016748	APZ42_020109	A0A165A4L9	A0A164Y0Q5	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	PKS_ER domain-containing protein.	0.638
APZ42_016748	APZ42_023861	A0A165A4L9	A0A0P5BBM6	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Non-specific lipid-transfer protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.855
APZ42_016748	APZ42_030783	A0A165A4L9	A0A164NBZ1	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Hydroxysteroid dehydrogenase protein 2.	0.942
APZ42_016748	APZ42_031583	A0A165A4L9	A0A164MQN5	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.706
APZ42_016748	APZ42_032739	A0A165A4L9	A0A164LU31	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Sorbitol dehydrogenase.	0.571
APZ42_017098	APZ42_018618	A0A0P5YMZ4	A0A162CPJ4	Putative Sulfite oxidase, mitochondrial.	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	0.403
APZ42_017098	APZ42_020109	A0A0P5YMZ4	A0A164Y0Q5	Putative Sulfite oxidase, mitochondrial.	PKS_ER domain-containing protein.	0.886
APZ42_017098	APZ42_030783	A0A0P5YMZ4	A0A164NBZ1	Putative Sulfite oxidase, mitochondrial.	Hydroxysteroid dehydrogenase protein 2.	0.403
APZ42_017098	APZ42_031583	A0A0P5YMZ4	A0A164MQN5	Putative Sulfite oxidase, mitochondrial.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.510
APZ42_017098	APZ42_033871	A0A0P5YMZ4	A0A164KNT3	Putative Sulfite oxidase, mitochondrial.	Leucine-rich repeat kinase.	0.616
APZ42_018618	APZ42_012675	A0A162CPJ4	A0A162RK30	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	Phosphotransferase.	0.538
APZ42_018618	APZ42_016748	A0A162CPJ4	A0A165A4L9	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.942
APZ42_018618	APZ42_017098	A0A162CPJ4	A0A0P5YMZ4	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	Putative Sulfite oxidase, mitochondrial.	0.403
APZ42_018618	APZ42_020109	A0A162CPJ4	A0A164Y0Q5	Hydroxysteroid dehydrogenase 2-like protein; Belongs to the G-protein coupled receptor 1 family.	PKS_ER domain-containing protein.	0.796

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.903

expected number of edges:

10

PPI enrichment p-value:

1.06e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006744

Ubiquinone biosynthetic process

10 of 17

2.31

7.86

6.69e-19

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

3 of 4

2.42

1.78

0.00047

GO:0016705

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

4 of 27

1.71

1.53

0.00047

GO:0071949

FAD binding

3 of 15

1.84

1.32

0.0022

GO:0102208

2-polyprenyl-6-hydroxyphenol methylase activity

2 of 3

2.37

1.09

0.0097

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

2 of 3

2.37

1.09

0.0097

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0110142

Ubiquinone biosynthesis complex

4 of 5

2.45

3.23

6.24e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3314

Ubiquinone metabolic process

9 of 14

2.35

7.29

7.38e-17

CL:3316

Ubiquinone biosynthesis complex, and Ubiquinone biosynthesis O-methyltransferase

7 of 7

2.54

6.55

6.37e-14

CL:3309

Mixed, incl. Ubiquinone metabolic process, and Translocase

10 of 50

1.84

4.9

1.17e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

amg00130

Ubiquinone and other terpenoid-quinone biosynthesis

8 of 14

2.3

6.47

4.82e-15

amg01110

Biosynthesis of secondary metabolites

8 of 289

0.99

1.04

8.45e-06

amg01100

Metabolic pathways

8 of 650

0.63

0.49

0.0026

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0110142

Ubiquinone biosynthesis complex

6 of 14

2.18

4.16

1.27e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

8 of 15

2.27

6.2

1.56e-14

KW-0831

Ubiquinone biosynthesis

5 of 7

2.4

4.14

5.99e-09

KW-0949

S-adenosyl-L-methionine

3 of 59

1.25

0.6

0.0465

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13489

Methyltransferase domain

3 of 8

2.12

1.45

0.0017

PF08491

Squalene epoxidase

2 of 2

2.54

1.03

0.0134

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR010971

Ubiquinone biosynthesis hydroxylase UbiH/COQ6

3 of 3

2.54

1.77

0.00053

IPR002938

FAD-binding domain

3 of 4

2.42

1.76

0.00053

IPR018168

Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6, conserved site

2 of 2

2.54

0.9

0.0227

IPR010233

Ubiquinone biosynthesis O-methyltransferase

2 of 2

2.54

0.9

0.0227

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 34

1.49

0.68

0.0392

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