STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
APZ42_019004Poly [ADP-ribose] polymerase. (1009 aa)    
Predicted Functional Partners:
APZ42_014238
Poly(ADP-ribose) glycohydrolase.
  
 
 0.955
APZ42_016995
UPF0609 protein.
    
 
 0.953
APZ42_018475
X-ray repair cross-complementing protein 5.
   
 
 0.935
APZ42_032559
X-ray repair cross-complementing protein 6.
   
 
 0.930
Fen1
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]
   
 0.880
APZ42_034343
Poly(ADP-ribose) glycohydrolase.
    
 0.878
APZ42_013600
DNA repair protein complementing XP-C cells.
    
 0.870
APZ42_026256
Caspase-1; Belongs to the peptidase C14A family.
    
 0.863
APZ42_020714
Caspase-1; Belongs to the peptidase C14A family.
    
 0.863
APZ42_022104
Putative Breast cancer type 2 susceptibility protein.
    
 0.850
Your Current Organism:
Daphnia magna
NCBI taxonomy Id: 35525
Other names: D. magna
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.