APZ42_016995 protein (Daphnia magna) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

APZ42_016995

UPF0609 protein. (350 aa)

Predicted Functional Partners:

APZ42_019004

0.953

APZ42_020645

0.874

APZ42_014238

0.501

APZ42_002289

0.499

APZ42_019142

0.441

APZ42_005183

0.441

APZ42_006167

0.441

APZ42_028144

0.441

Your Current Organism:

Daphnia magna

NCBI taxonomy Id: 35525
Other names: D. magna

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APZ42_002289	APZ42_016995	A0A164IDE6	A0A165AA68	Putative Pre-mRNA-splicing factor CWC22.	UPF0609 protein.	0.499
APZ42_005183	APZ42_016995	A0A0P5ZCW6	A0A165AA68	Histone H2A; Belongs to the histone H2A family.	UPF0609 protein.	0.441
APZ42_005183	APZ42_019004	A0A0P5ZCW6	A0A164YKT3	Histone H2A; Belongs to the histone H2A family.	Poly [ADP-ribose] polymerase.	0.540
APZ42_005183	APZ42_020645	A0A0P5ZCW6	A0A162CC77	Histone H2A; Belongs to the histone H2A family.	Uncharacterized protein.	0.540
APZ42_006167	APZ42_016995	A0A164G200	A0A165AA68	Histone H2A; Belongs to the histone H2A family.	UPF0609 protein.	0.441
APZ42_006167	APZ42_019004	A0A164G200	A0A164YKT3	Histone H2A; Belongs to the histone H2A family.	Poly [ADP-ribose] polymerase.	0.540
APZ42_006167	APZ42_020645	A0A164G200	A0A162CC77	Histone H2A; Belongs to the histone H2A family.	Uncharacterized protein.	0.540
APZ42_014238	APZ42_016995	A0A0P5Y1S9	A0A165AA68	Poly(ADP-ribose) glycohydrolase.	UPF0609 protein.	0.501
APZ42_014238	APZ42_019004	A0A0P5Y1S9	A0A164YKT3	Poly(ADP-ribose) glycohydrolase.	Poly [ADP-ribose] polymerase.	0.955
APZ42_014238	APZ42_020645	A0A0P5Y1S9	A0A162CC77	Poly(ADP-ribose) glycohydrolase.	Uncharacterized protein.	0.878
APZ42_016995	APZ42_002289	A0A165AA68	A0A164IDE6	UPF0609 protein.	Putative Pre-mRNA-splicing factor CWC22.	0.499
APZ42_016995	APZ42_005183	A0A165AA68	A0A0P5ZCW6	UPF0609 protein.	Histone H2A; Belongs to the histone H2A family.	0.441
APZ42_016995	APZ42_006167	A0A165AA68	A0A164G200	UPF0609 protein.	Histone H2A; Belongs to the histone H2A family.	0.441
APZ42_016995	APZ42_014238	A0A165AA68	A0A0P5Y1S9	UPF0609 protein.	Poly(ADP-ribose) glycohydrolase.	0.501
APZ42_016995	APZ42_019004	A0A165AA68	A0A164YKT3	UPF0609 protein.	Poly [ADP-ribose] polymerase.	0.953
APZ42_016995	APZ42_019142	A0A165AA68	A0A0P5VFK6	UPF0609 protein.	Histone H2A; Belongs to the histone H2A family.	0.441
APZ42_016995	APZ42_020645	A0A165AA68	A0A162CC77	UPF0609 protein.	Uncharacterized protein.	0.874
APZ42_016995	APZ42_028144	A0A165AA68	A0A164QSQ0	UPF0609 protein.	Histone H2A; Belongs to the histone H2A family.	0.441
APZ42_019004	APZ42_005183	A0A164YKT3	A0A0P5ZCW6	Poly [ADP-ribose] polymerase.	Histone H2A; Belongs to the histone H2A family.	0.540
APZ42_019004	APZ42_006167	A0A164YKT3	A0A164G200	Poly [ADP-ribose] polymerase.	Histone H2A; Belongs to the histone H2A family.	0.540

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.764

expected number of edges:

31

PPI enrichment p-value:

0.768

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016579

Protein deubiquitination

6 of 58

2.25

4.1

3.09e-09

GO:1903051

Negative regulation of proteolysis involved in protein catabolic process

3 of 12

2.63

2.18

9.31e-05

GO:0006511

Ubiquitin-dependent protein catabolic process

5 of 299

1.46

1.38

0.00036

GO:0030162

Regulation of proteolysis

4 of 240

1.45

1.08

0.0032

GO:0007094

Mitotic spindle assembly checkpoint signaling

2 of 15

2.36

1.05

0.0114

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004843

Cysteine-type deubiquitinase activity

5 of 48

2.25

3.42

1.26e-07

GO:0004197

Cysteine-type endopeptidase activity

5 of 71

2.08

3.16

2.01e-07

GO:0140096

Catalytic activity, acting on a protein

6 of 1524

0.83

0.51

0.0219

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005634

Nucleus

9 of 3640

0.63

0.42

0.0151

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9211

Mixed, incl. Peptidase C19, ubiquitin carboxyl-terminal hydrolase, and HELP motif

6 of 12

2.93

6.63

3.60e-13

CL:9129

Processing of Intronless Pre-mRNAs, and Peptidase C19, ubiquitin carboxyl-terminal hydrolase

7 of 53

2.35

5.7

9.91e-13

CL:9214

Regulation of protein localization to cell surface, and Peptidase C19, ubiquitin carboxyl-terminal hydrolase

4 of 6

3.06

4.33

1.14e-08

CL:5274

Mixed, incl. Male germ-line stem cell asymmetric division, and Meiotic sister chromatid cohesion

2 of 6

2.75

1.24

0.0056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689880

Ub-specific processing proteases

4 of 182

1.57

1.11

0.0039

MAP-5688426

Deubiquitination

4 of 250

1.44

0.96

0.0068

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

2 of 18

2.28

0.86

0.0266

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

2 of 18

2.28

0.86

0.0266

MAP-179409

APC-Cdc20 mediated degradation of Nek2A

2 of 22

2.19

0.85

0.0266

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13423

Ubiquitin carboxyl-terminal hydrolase

3 of 13

2.6

2.16

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001394

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

4 of 22

2.49

2.88

3.41e-06

IPR028889

Ubiquitin specific protease domain

4 of 24

2.45

2.87

3.41e-06

IPR038765

Papain-like cysteine peptidase superfamily

5 of 101

1.93

2.52

3.41e-06

IPR018200

Ubiquitin specific protease, conserved site

3 of 20

2.41

1.93

0.00024

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