node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | SOVF_000900 | A0A0K9QKF0 | A0A0K9S4C1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 0.959 |
FEN1 | SOVF_044610 | A0A0K9QKF0 | A0A0K9RP82 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein; Belongs to the RecA family. | 0.594 |
FEN1 | SOVF_062630 | A0A0K9QKF0 | A0A0K9RIF4 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.849 |
FEN1 | SOVF_063370 | A0A0K9QKF0 | A0A0K9RJY9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RECA_2 domain-containing protein. | 0.594 |
FEN1 | SOVF_072760 | A0A0K9QKF0 | A0A0K9RHC2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 3'-5' exonuclease domain-containing protein. | 0.959 |
FEN1 | SOVF_132640 | A0A0K9QKF0 | A0A0K9QWQ2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein; Belongs to the RecA family. | 0.744 |
FEN1 | SOVF_138960 | A0A0K9QKF0 | A0A0K9QUV2 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein; Belongs to the RecA family. | 0.581 |
FEN1 | SOVF_143750 | A0A0K9QKF0 | A0A0K9QTC3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RECA_2 domain-containing protein. | 0.448 |
FEN1 | SOVF_152150 | A0A0K9QKF0 | A0A0K9QQT5 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | PEROXIDASE_4 domain-containing protein. | 0.555 |
FEN1 | SOVF_177100 | A0A0K9QKF0 | A0A0K9QHX1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | RECA_2 domain-containing protein. | 0.755 |
SOVF_000900 | FEN1 | A0A0K9S4C1 | A0A0K9QKF0 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.959 |
SOVF_000900 | SOVF_044610 | A0A0K9S4C1 | A0A0K9RP82 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Uncharacterized protein; Belongs to the RecA family. | 0.882 |
SOVF_000900 | SOVF_062630 | A0A0K9S4C1 | A0A0K9RIF4 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family. | 0.404 |
SOVF_000900 | SOVF_063370 | A0A0K9S4C1 | A0A0K9RJY9 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | RECA_2 domain-containing protein. | 0.882 |
SOVF_000900 | SOVF_072760 | A0A0K9S4C1 | A0A0K9RHC2 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | 3'-5' exonuclease domain-containing protein. | 0.640 |
SOVF_000900 | SOVF_132640 | A0A0K9S4C1 | A0A0K9QWQ2 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Uncharacterized protein; Belongs to the RecA family. | 0.811 |
SOVF_000900 | SOVF_138960 | A0A0K9S4C1 | A0A0K9QUV2 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | Uncharacterized protein; Belongs to the RecA family. | 0.811 |
SOVF_000900 | SOVF_143750 | A0A0K9S4C1 | A0A0K9QTC3 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | RECA_2 domain-containing protein. | 0.927 |
SOVF_000900 | SOVF_152150 | A0A0K9S4C1 | A0A0K9QQT5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | PEROXIDASE_4 domain-containing protein. | 0.960 |
SOVF_000900 | SOVF_177100 | A0A0K9S4C1 | A0A0K9QHX1 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. | RECA_2 domain-containing protein. | 0.977 |