SOVF_086380 protein (Spinacia oleracea) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SOVF_086380

tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (477 aa)

Predicted Functional Partners:

SOVF_155910

0.825

SOVF_134740

0.674

SOVF_036770

0.669

SOVF_010060

0.669

SOVF_032770

0.599

SOVF_204210

0.595

SOVF_145130

0.564

SOVF_031710

0.551

SOVF_092840

0.530

SOVF_133930

0.524

Your Current Organism:

Spinacia oleracea

NCBI taxonomy Id: 3562
Other names: S. oleracea, Spinacea oleracea, Spinacia oleracea L., spinach

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SOVF_010060	SOVF_031710	A0A0K9RZW1	A0A0K9RUN8	Uncharacterized protein.	Uncharacterized protein.	0.425
SOVF_010060	SOVF_032770	A0A0K9RZW1	A0A0K9RSZ8	Uncharacterized protein.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.517
SOVF_010060	SOVF_086380	A0A0K9RZW1	A0A0K9RB53	Uncharacterized protein.	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	0.669
SOVF_010060	SOVF_092840	A0A0K9RZW1	A0A0K9R8X5	Uncharacterized protein.	Uncharacterized protein.	0.497
SOVF_010060	SOVF_133930	A0A0K9RZW1	A0A0K9QWC8	Uncharacterized protein.	UPF0020 domain-containing protein.	0.967
SOVF_010060	SOVF_145130	A0A0K9RZW1	A0A0K9QSX9	Uncharacterized protein.	tRNA (adenine(58)-N(1))-methyltransferase.	0.524
SOVF_010060	SOVF_155910	A0A0K9RZW1	A0A0K9QR50	Uncharacterized protein.	SAM_MT_TRM5_TYW2 domain-containing protein.	0.897
SOVF_031710	SOVF_010060	A0A0K9RUN8	A0A0K9RZW1	Uncharacterized protein.	Uncharacterized protein.	0.425
SOVF_031710	SOVF_036770	A0A0K9RUN8	A0A0K9RTC2	Uncharacterized protein.	Uncharacterized protein.	0.425
SOVF_031710	SOVF_086380	A0A0K9RUN8	A0A0K9RB53	Uncharacterized protein.	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	0.551
SOVF_031710	SOVF_092840	A0A0K9RUN8	A0A0K9R8X5	Uncharacterized protein.	Uncharacterized protein.	0.514
SOVF_031710	SOVF_133930	A0A0K9RUN8	A0A0K9QWC8	Uncharacterized protein.	UPF0020 domain-containing protein.	0.492
SOVF_031710	SOVF_134740	A0A0K9RUN8	A0A0K9QW58	Uncharacterized protein.	C3H1-type domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	0.456
SOVF_031710	SOVF_145130	A0A0K9RUN8	A0A0K9QSX9	Uncharacterized protein.	tRNA (adenine(58)-N(1))-methyltransferase.	0.659
SOVF_031710	SOVF_155910	A0A0K9RUN8	A0A0K9QR50	Uncharacterized protein.	SAM_MT_TRM5_TYW2 domain-containing protein.	0.425
SOVF_031710	SOVF_204210	A0A0K9RUN8	A0A0K9Q9J7	Uncharacterized protein.	SAM-dependent MTase TRM10-type domain-containing protein.	0.547
SOVF_032770	SOVF_010060	A0A0K9RSZ8	A0A0K9RZW1	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Uncharacterized protein.	0.517
SOVF_032770	SOVF_036770	A0A0K9RSZ8	A0A0K9RTC2	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Uncharacterized protein.	0.517
SOVF_032770	SOVF_086380	A0A0K9RSZ8	A0A0K9RB53	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family.	0.599
SOVF_032770	SOVF_092840	A0A0K9RSZ8	A0A0K9R8X5	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	Uncharacterized protein.	0.843

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006869

Lipid transport

4 of 32

1.57

1.3

0.0012

GO:0051701

Biological process involved in interaction with host

7 of 152

1.14

1.1

0.00019

GO:0044409

Entry into host

2 of 7

1.93

0.71

0.0463

GO:0044406

Adhesion of symbiont to host

2 of 7

1.93

0.71

0.0463

GO:0044114

Development of symbiont in host

2 of 9

1.82

0.7

0.0463

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005548

Phospholipid transporter activity

3 of 14

1.81

0.95

0.0138

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043190

ATP-binding cassette (ABC) transporter complex

3 of 28

1.51

0.85

0.0153

GO:0016021

Integral component of membrane

7 of 663

0.5

0.32

0.0392

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4538

Virulence factor Mce protein, and Permease MlaE

10 of 17

2.25

7.45

1.65e-18

CL:4533

Mce/MlaD, and Permease MlaE

11 of 60

1.74

4.61

5.10e-17

CL:4557

Cholesterol uptake porter CUP1 of Mce4, putative, and Mammalian cell entry, C-terminal

5 of 5

2.48

4.43

2.04e-09

CL:4540

Virulence factor Mce protein, and Organic hydroxy compound transport

2 of 8

1.87

0.84

0.0239

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

11 of 150

1.34

2.43

3.60e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635465

Suppression of apoptosis

7 of 45

1.67

3.04

1.45e-09

MAP-9637690

Response of Mtb to phagocytosis

7 of 96

1.34

1.9

1.02e-07

MAP-9635486

Infection with Mycobacterium tuberculosis

7 of 178

1.07

1.2

4.10e-06

MAP-5663205

Infectious disease

7 of 180

1.07

1.19

4.10e-06

MAP-1643685

Disease

7 of 185

1.05

1.17

4.10e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990351

Transporter complex

4 of 52

1.36

0.93

0.0066

GOCC:0043190

ATP-binding cassette (ABC) transporter complex

3 of 36

1.4

0.68

0.0344

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1133

Transmembrane helix

9 of 611

0.64

0.5

0.0021

KW-0812

Transmembrane

9 of 611

0.64

0.5

0.0021

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02470

MlaD protein

7 of 42

1.7

2.88

1.55e-08

PF11887

Cholesterol uptake porter CUP1 of Mce4, putative

4 of 9

2.12

2.46

1.13e-05

PF02405

Permease MlaE

3 of 14

1.81

1.25

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005693

Virulence factor Mce protein

7 of 30

1.84

3.33

5.06e-09

IPR024516

Mammalian cell entry, C-terminal

6 of 25

1.86

2.99

7.95e-08

IPR003399

Mce/MlaD

7 of 42

1.7

2.85

2.08e-08

IPR030802

ABC transporter permease MalE

3 of 14

1.81

1.12

0.0059

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About