SOVF_069420 protein (Spinacia oleracea) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SOVF_069420

Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family. (126 aa)

Predicted Functional Partners:

SOVF_153990

0.996

SOVF_105860

0.996

SOVF_165710

0.994

SOVF_075980

0.991

SOVF_211780

0.985

SOVF_033720

0.970

SOVF_083650

0.853

SOVF_080100

0.849

SOVF_162650

0.802

SOVF_001900

0.785

Your Current Organism:

Spinacia oleracea

NCBI taxonomy Id: 3562
Other names: S. oleracea, Spinacea oleracea, Spinacia oleracea L., spinach

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SOVF_001900	SOVF_033720	A0A0K9S2G8	A0A0K9RSQ5	Uncharacterized protein.	Uncharacterized protein.	0.497
SOVF_001900	SOVF_069420	A0A0K9S2G8	A0A0K9RGH7	Uncharacterized protein.	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	0.785
SOVF_001900	SOVF_083650	A0A0K9S2G8	A0A0K9RC41	Uncharacterized protein.	Uncharacterized protein.	0.548
SOVF_001900	SOVF_105860	A0A0K9S2G8	A0A0K9R551	Uncharacterized protein.	Uncharacterized protein.	0.690
SOVF_001900	SOVF_153990	A0A0K9S2G8	A0A0K9QQ40	Uncharacterized protein.	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.	0.443
SOVF_001900	SOVF_165710	A0A0K9S2G8	A0A0K9QLI8	Uncharacterized protein.	Uncharacterized protein.	0.835
SOVF_001900	SOVF_211780	A0A0K9S2G8	A0A0K9Q7H3	Uncharacterized protein.	Uncharacterized protein.	0.497
SOVF_033720	SOVF_001900	A0A0K9RSQ5	A0A0K9S2G8	Uncharacterized protein.	Uncharacterized protein.	0.497
SOVF_033720	SOVF_069420	A0A0K9RSQ5	A0A0K9RGH7	Uncharacterized protein.	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	0.970
SOVF_033720	SOVF_075980	A0A0K9RSQ5	A0A0K9RED5	Uncharacterized protein.	Uncharacterized protein.	0.985
SOVF_033720	SOVF_080100	A0A0K9RSQ5	A0A0K9RD41	Uncharacterized protein.	Uncharacterized protein.	0.704
SOVF_033720	SOVF_083650	A0A0K9RSQ5	A0A0K9RC41	Uncharacterized protein.	Uncharacterized protein.	0.639
SOVF_033720	SOVF_105860	A0A0K9RSQ5	A0A0K9R551	Uncharacterized protein.	Uncharacterized protein.	0.990
SOVF_033720	SOVF_153990	A0A0K9RSQ5	A0A0K9QQ40	Uncharacterized protein.	Prefoldin subunit 3; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit alpha family.	0.984
SOVF_033720	SOVF_162650	A0A0K9RSQ5	A0A0K9QP21	Uncharacterized protein.	Uncharacterized protein.	0.685
SOVF_033720	SOVF_165710	A0A0K9RSQ5	A0A0K9QLI8	Uncharacterized protein.	Uncharacterized protein.	0.989
SOVF_069420	SOVF_001900	A0A0K9RGH7	A0A0K9S2G8	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	Uncharacterized protein.	0.785
SOVF_069420	SOVF_033720	A0A0K9RGH7	A0A0K9RSQ5	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	Uncharacterized protein.	0.970
SOVF_069420	SOVF_075980	A0A0K9RGH7	A0A0K9RED5	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	Uncharacterized protein.	0.991
SOVF_069420	SOVF_080100	A0A0K9RGH7	A0A0K9RD41	Prefoldin subunit 4; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins; Belongs to the prefoldin subunit beta family.	Uncharacterized protein.	0.849

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.842

expected number of edges:

12

PPI enrichment p-value:

0.000188

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009395

Phospholipid catabolic process

3 of 11

2.34

1.91

0.00025

GO:0046486

Glycerolipid metabolic process

5 of 102

1.6

1.65

0.00012

GO:0016042

Lipid catabolic process

5 of 104

1.59

1.64

0.00012

GO:0006644

Phospholipid metabolic process

5 of 126

1.51

1.5

0.00019

GO:0006650

Glycerophospholipid metabolic process

4 of 91

1.55

1.27

0.0013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004691

cAMP-dependent protein kinase activity

3 of 4

2.78

2.32

5.69e-05

GO:0016298

Lipase activity

4 of 39

1.92

2.03

5.69e-05

GO:0004620

Phospholipase activity

3 of 16

2.18

1.81

0.00033

GO:0052689

Carboxylic ester hydrolase activity

4 of 65

1.7

1.59

0.00031

GO:0004679

AMP-activated protein kinase activity

2 of 2

2.91

1.52

0.0018

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11877

Glycerophospholipid metabolism, and Triglyceride metabolic process

5 of 67

1.78

2.08

2.15e-05

CL:3125

DARPP-32 events, and G protein activity

3 of 11

2.34

1.96

0.00020

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

7 of 94

1.78

3.38

9.54e-10

map00565

Ether lipid metabolism

3 of 28

1.94

1.65

0.00048

map00591

Linoleic acid metabolism

2 of 9

2.25

1.29

0.0039

map00590

Arachidonic acid metabolism

2 of 18

1.95

1.04

0.0100

map00592

alpha-Linolenic acid metabolism

2 of 27

1.78

0.9

0.0170

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-111996

Ca-dependent events

4 of 7

2.66

3.42

3.85e-07

MAP-112043

PLC beta mediated events

4 of 9

2.56

3.37

4.17e-07

MAP-112040

G-protein mediated events

4 of 9

2.56

3.37

4.17e-07

MAP-111885

Opioid Signalling

4 of 10

2.51

3.34

4.17e-07

MAP-418594

G alpha (i) signalling events

4 of 14

2.36

3.16

7.12e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005952

cAMP-dependent protein kinase complex

3 of 5

2.69

2.23

7.67e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0442

Lipid degradation

4 of 11

2.47

3.33

4.06e-07

KW-0378

Hydrolase

4 of 341

0.98

0.51

0.0466

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03009

Glycerophosphoryl diester phosphodiesterase family

2 of 4

2.61

0.95

0.0188

PF01734

Patatin-like phospholipase

2 of 6

2.43

0.94

0.0188

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016035

Acyl transferase/acyl hydrolase/lysophospholipase

4 of 14

2.36

2.61

1.00e-05

IPR002642

Lysophospholipase, catalytic domain

2 of 2

2.91

1.09

0.0109

IPR030395

Glycerophosphodiester phosphodiesterase domain

2 of 4

2.61

0.96

0.0182

IPR002641

Patatin-like phospholipase domain

2 of 6

2.43

0.87

0.0254

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00022

Cytoplasmic phospholipase A2, catalytic subunit

2 of 2

2.91

1.43

0.0026

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