SDQ46338.1 protein (Thermostaphylospora chromogena)

Network Stats

number of nodes:

number of edges:

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045669

Positive regulation of osteoblast differentiation

9 of 54

2.49

8.36

1.67e-18

GO:0030509

BMP signaling pathway

10 of 79

2.37

8.35

1.34e-19

GO:0007178

Transmembrane receptor protein serine/threonine kinase signaling pathway

11 of 163

2.1

7.07

1.34e-19

GO:0030501

Positive regulation of bone mineralization

7 of 41

2.5

6.44

8.32e-14

GO:0010862

Positive regulation of pathway-restricted SMAD protein phosphorylation

7 of 48

2.44

6.14

2.10e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046332

SMAD binding

7 of 61

2.33

5.46

3.21e-12

GO:0004675

Transmembrane receptor protein serine/threonine kinase activity

5 of 16

2.77

4.94

4.80e-10

GO:0098821

BMP receptor activity

4 of 6

3.1

4.38

9.74e-09

GO:0005024

Transforming growth factor beta receptor activity

4 of 10

2.87

4.03

3.48e-08

GO:0019211

Phosphatase activator activity

4 of 15

2.7

3.72

1.08e-07

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071144

Heteromeric SMAD protein complex

3 of 7

2.9

2.58

1.91e-05

GO:0043235

Receptor complex

6 of 354

1.5

1.77

1.91e-05

GO:0071142

Homomeric SMAD protein complex

2 of 2

3.27

1.77

0.00064

GO:0070724

BMP receptor complex

2 of 4

2.97

1.59

0.0013

GO:0048179

Activin receptor complex

2 of 5

2.87

1.56

0.0015

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:29097342

(2018) Variable signaling activity by FOP ACVR1 mutations.

8 of 9

3.22

9.52

2.24e-18

PMID:24586530

(2014) Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis.

7 of 15

2.94

7.12

4.04e-14

PMID:32368260

(2019) Transforming growth factor-beta family members are regulated during induced luteolysis in cattle.

7 of 24

2.74

6.43

4.14e-13

PMID:34745928

(2021) The Prognostic Value of Bone Morphogenetic Proteins and Their Receptors in Lung Adenocarcinoma.

7 of 25

2.72

6.41

4.14e-13

PMID:35580897

(2022) Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.

7 of 26

2.7

6.4

4.14e-13

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15382

Signaling by BMP, and Transforming growth factor beta, conserved site

11 of 38

2.73

12.43

1.79e-26

CL:15385

Signaling by BMP, and Neural fold elevation formation

9 of 21

2.9

11.0

3.71e-22

CL:15407

Activin types I and II receptor domain, and Chondrogenesis

6 of 10

3.05

7.33

2.16e-14

CL:15410

BMP signaling pathway involved in heart development, and Heart induction

5 of 5

3.27

6.39

2.05e-12

CL:15387

Heteromeric SMAD protein complex, and c-SKI Smad4 binding domain

3 of 8

2.85

2.75

9.03e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ocu04350

TGF-beta signaling pathway

11 of 81

2.41

10.1

2.51e-24

ocu04550

Signaling pathways regulating pluripotency of stem cells

10 of 113

2.22

7.75

7.17e-20

ocu04390

Hippo signaling pathway

7 of 121

2.03

4.63

8.10e-12

ocu04060

Cytokine-cytokine receptor interaction

8 of 222

1.83

4.1

3.78e-12

ocu05418

Fluid shear stress and atherosclerosis

6 of 106

2.03

3.99

6.75e-10

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-201451

Signaling by BMP

8 of 25

2.78

8.97

2.41e-18

MAP-9006936

Signaling by TGFB family members

10 of 123

2.18

7.18

1.65e-18

MAP-1502540

Signaling by Activin

3 of 14

2.6

2.42

3.26e-05

MAP-162582

Signal Transduction

10 of 3071

0.79

0.74

2.97e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070724

BMP receptor complex

3 of 5

3.05

2.73

1.11e-05

GOCC:0071141

SMAD protein complex

3 of 9

2.8

2.56

1.97e-05

GOCC:0098802

Plasma membrane signaling receptor complex

5 of 177

1.72

2.03

1.97e-05

GOCC:0048180

Activin complex

2 of 5

2.87

1.61

0.0012

GOCC:0005887

Integral component of plasma membrane

5 of 458

1.31

1.15

0.00081

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0723

Serine/threonine-protein kinase

5 of 190

1.69

2.06

1.30e-05

KW-0892

Osteogenesis

2 of 3

3.1

1.91

0.00035

KW-0891

Chondrogenesis

2 of 6

2.8

1.77

0.00059

KW-0464

Manganese

3 of 51

2.04

1.75

0.00035

KW-0339

Growth factor

3 of 78

1.86

1.56

0.00064

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01064

Activin types I and II receptor domain

5 of 7

3.13

5.76

2.64e-11

PF00688

TGF-beta propeptide

3 of 28

2.3

1.72

0.00056

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000472

Activin types I and II receptor domain

5 of 8

3.07

5.37

1.32e-10

IPR000333

Ser/Thr protein kinase, TGFB receptor

5 of 11

2.93

5.19

2.24e-10

IPR045860

Snake toxin-like superfamily

5 of 28

2.52

4.18

8.08e-09

IPR036578

SMAD MH1 domain superfamily

3 of 6

2.97

2.63

1.64e-05

IPR013019

MAD homology, MH1

3 of 6

2.97

2.63

1.64e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00467

GS motif

3 of 6

2.97

2.81

7.49e-06

SM00524

Domain B in dwarfin family proteins

3 of 8

2.85

2.79

7.49e-06

SM00523

Domain A in dwarfin family proteins

3 of 8

2.85

2.79

7.49e-06

SM00204

Transforming growth factor-beta (TGF-beta) family

3 of 33

2.23

1.97

0.00016

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDQ46251.1	SDQ46276.1	SAMN04489764_0773	SAMN04489764_0774	Transglycosylase SLT domain-containing protein.	Hypothetical protein.	0.790
SDQ46251.1	SDQ46308.1	SAMN04489764_0773	SAMN04489764_0775	Transglycosylase SLT domain-containing protein.	TrbL/VirB6 plasmid conjugal transfer protein.	0.889
SDQ46251.1	SDQ46338.1	SAMN04489764_0773	SAMN04489764_0776	Transglycosylase SLT domain-containing protein.	AAA-like domain-containing protein.	0.899
SDQ46251.1	SDQ46365.1	SAMN04489764_0773	SAMN04489764_0777	Transglycosylase SLT domain-containing protein.	MinD-like ATPase involved in chromosome partitioning or flagellar assembly.	0.587
SDQ46251.1	SDR25661.1	SAMN04489764_0773	SAMN04489764_4518	Transglycosylase SLT domain-containing protein.	Sulfotransferase family protein.	0.406
SDQ46276.1	SDQ46251.1	SAMN04489764_0774	SAMN04489764_0773	Hypothetical protein.	Transglycosylase SLT domain-containing protein.	0.790
SDQ46276.1	SDQ46308.1	SAMN04489764_0774	SAMN04489764_0775	Hypothetical protein.	TrbL/VirB6 plasmid conjugal transfer protein.	0.790
SDQ46276.1	SDQ46338.1	SAMN04489764_0774	SAMN04489764_0776	Hypothetical protein.	AAA-like domain-containing protein.	0.785
SDQ46276.1	SDQ46365.1	SAMN04489764_0774	SAMN04489764_0777	Hypothetical protein.	MinD-like ATPase involved in chromosome partitioning or flagellar assembly.	0.519
SDQ46308.1	SDQ46251.1	SAMN04489764_0775	SAMN04489764_0773	TrbL/VirB6 plasmid conjugal transfer protein.	Transglycosylase SLT domain-containing protein.	0.889
SDQ46308.1	SDQ46276.1	SAMN04489764_0775	SAMN04489764_0774	TrbL/VirB6 plasmid conjugal transfer protein.	Hypothetical protein.	0.790
SDQ46308.1	SDQ46338.1	SAMN04489764_0775	SAMN04489764_0776	TrbL/VirB6 plasmid conjugal transfer protein.	AAA-like domain-containing protein.	0.959
SDQ46308.1	SDQ46365.1	SAMN04489764_0775	SAMN04489764_0777	TrbL/VirB6 plasmid conjugal transfer protein.	MinD-like ATPase involved in chromosome partitioning or flagellar assembly.	0.798
SDQ46308.1	SDQ71444.1	SAMN04489764_0775	SAMN04489764_1819	TrbL/VirB6 plasmid conjugal transfer protein.	GTP cyclohydrolase III; Manually curated.	0.741
SDQ46308.1	SDQ71831.1	SAMN04489764_0775	SAMN04489764_1835	TrbL/VirB6 plasmid conjugal transfer protein.	Uncharacterized conserved protein, LabA/DUF88 family.	0.709
SDQ46308.1	SDQ94931.1	SAMN04489764_0775	SAMN04489764_2741	TrbL/VirB6 plasmid conjugal transfer protein.	DivIVA protein.	0.605
SDQ46308.1	SDR25661.1	SAMN04489764_0775	SAMN04489764_4518	TrbL/VirB6 plasmid conjugal transfer protein.	Sulfotransferase family protein.	0.771
SDQ46308.1	SDR31793.1	SAMN04489764_0775	SAMN04489764_5097	TrbL/VirB6 plasmid conjugal transfer protein.	Hypothetical protein.	0.773
SDQ46308.1	SDR33171.1	SAMN04489764_0775	SAMN04489764_5255	TrbL/VirB6 plasmid conjugal transfer protein.	Nuclease-related domain-containing protein.	0.766
SDQ46338.1	SDQ46251.1	SAMN04489764_0776	SAMN04489764_0773	AAA-like domain-containing protein.	Transglycosylase SLT domain-containing protein.	0.899

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