STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDQ64454.1Transmembrane protein of unknown function; Manually curated. (271 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
    0.765
SDQ53075.1
Protein of unknown function.
  
     0.761
SDR31397.1
Protein of unknown function.
  
     0.733
SDQ64378.1
Predicted nucleic acid-binding protein, contains Zn-ribbon domain (includes truncated derivatives).
 
     0.719
SDQ61151.1
NAD(P)H dehydrogenase (quinone); Belongs to the WrbA family.
   
    0.714
rbpA
RNA polymerase-binding protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
     0.696
SDR07452.1
Protein of unknown function.
  
     0.658
SDR18078.1
MerR HTH family regulatory protein.
  
     0.643
SDR30460.1
Protein of unknown function.
  
     0.639
whiB
Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.635
Your Current Organism:
Thermostaphylospora chromogena
NCBI taxonomy Id: 35622
Other names: ATCC 43196, Actinobifida chromogena, DSM 43794, IFO 16096, JCM 6244, NBRC 16096, NCIB 10212, NCIB:10212, NCIMB 10212, NRRL B-16983, T. chromogena, Thermomonospora chromogena, strain Agre no. 577
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