node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SEV98177.1 | SEW14313.1 | SAMN05421841_0472 | SAMN05421841_1245 | Cystathionine beta-synthase. | Cystathionine beta-synthase. | 0.911 |
SEV98177.1 | glyA | SAMN05421841_0472 | SAMN05421841_0294 | Cystathionine beta-synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
SEV98177.1 | trpA | SAMN05421841_0472 | SAMN05421841_2180 | Cystathionine beta-synthase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.918 |
SEV98177.1 | trpB | SAMN05421841_0472 | SAMN05421841_2179 | Cystathionine beta-synthase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.911 |
SEW14313.1 | SEV98177.1 | SAMN05421841_1245 | SAMN05421841_0472 | Cystathionine beta-synthase. | Cystathionine beta-synthase. | 0.911 |
SEW14313.1 | glyA | SAMN05421841_1245 | SAMN05421841_0294 | Cystathionine beta-synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.925 |
SEW14313.1 | trpA | SAMN05421841_1245 | SAMN05421841_2180 | Cystathionine beta-synthase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.918 |
SEW14313.1 | trpB | SAMN05421841_1245 | SAMN05421841_2179 | Cystathionine beta-synthase. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.911 |
SEW30856.1 | SEW30867.1 | SAMN05421841_2172 | SAMN05421841_2173 | Anthranilate synthase component 1. | Anthranilate synthase component 2. | 0.999 |
SEW30856.1 | SEW30893.1 | SAMN05421841_2172 | SAMN05421841_2175 | Anthranilate synthase component 1. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
SEW30856.1 | SEW44323.1 | SAMN05421841_2172 | SAMN05421841_3173 | Anthranilate synthase component 1. | Para-aminobenzoate synthetase component 1. | 0.932 |
SEW30856.1 | trpA | SAMN05421841_2172 | SAMN05421841_2180 | Anthranilate synthase component 1. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.958 |
SEW30856.1 | trpB | SAMN05421841_2172 | SAMN05421841_2179 | Anthranilate synthase component 1. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.968 |
SEW30856.1 | trpC | SAMN05421841_2172 | SAMN05421841_2176 | Anthranilate synthase component 1. | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.998 |
SEW30856.1 | trpF | SAMN05421841_2172 | SAMN05421841_2177 | Anthranilate synthase component 1. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.978 |
SEW30867.1 | SEW30856.1 | SAMN05421841_2173 | SAMN05421841_2172 | Anthranilate synthase component 2. | Anthranilate synthase component 1. | 0.999 |
SEW30867.1 | SEW30893.1 | SAMN05421841_2173 | SAMN05421841_2175 | Anthranilate synthase component 2. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.999 |
SEW30867.1 | SEW44323.1 | SAMN05421841_2173 | SAMN05421841_3173 | Anthranilate synthase component 2. | Para-aminobenzoate synthetase component 1. | 0.999 |
SEW30867.1 | trpA | SAMN05421841_2173 | SAMN05421841_2180 | Anthranilate synthase component 2. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.987 |
SEW30867.1 | trpB | SAMN05421841_2173 | SAMN05421841_2179 | Anthranilate synthase component 2. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.993 |