node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMG52646.1 | AMG52647.1 | AL524_05890 | AL524_05895 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | Protease modulator HflC; HflC and HflK could regulate a protease. | 0.999 |
AMG52646.1 | AMG52648.1 | AL524_05890 | AL524_05900 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.654 |
AMG52646.1 | hflB | AL524_05890 | AL524_23900 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | ATP-dependent metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.957 |
AMG52646.1 | hflX | AL524_05890 | AL524_05885 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | GTPase HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.886 |
AMG52646.1 | hfq | AL524_05890 | AL524_05880 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.864 |
AMG52646.1 | miaA | AL524_05890 | AL524_05875 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.803 |
AMG52646.1 | nnrE | AL524_05890 | AL524_05855 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | 0.518 |
AMG52646.1 | purA | AL524_05890 | AL524_05905 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.503 |
AMG52646.1 | yajC | AL524_05890 | AL524_20895 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | Preprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.518 |
AMG52646.1 | yidC | AL524_05890 | AL524_03015 | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.671 |
AMG52647.1 | AMG52646.1 | AL524_05895 | AL524_05890 | Protease modulator HflC; HflC and HflK could regulate a protease. | Cell division protein FtsH; HflC and HflK could encode or regulate a protease. | 0.999 |
AMG52647.1 | AMG52648.1 | AL524_05895 | AL524_05900 | Protease modulator HflC; HflC and HflK could regulate a protease. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.603 |
AMG52647.1 | hflB | AL524_05895 | AL524_23900 | Protease modulator HflC; HflC and HflK could regulate a protease. | ATP-dependent metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.944 |
AMG52647.1 | hflX | AL524_05895 | AL524_05885 | Protease modulator HflC; HflC and HflK could regulate a protease. | GTPase HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.751 |
AMG52647.1 | hfq | AL524_05895 | AL524_05880 | Protease modulator HflC; HflC and HflK could regulate a protease. | RNA chaperone Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.863 |
AMG52647.1 | miaA | AL524_05895 | AL524_05875 | Protease modulator HflC; HflC and HflK could regulate a protease. | tRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.785 |
AMG52647.1 | nnrE | AL524_05895 | AL524_05855 | Protease modulator HflC; HflC and HflK could regulate a protease. | Bifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] | 0.518 |
AMG52647.1 | purA | AL524_05895 | AL524_05905 | Protease modulator HflC; HflC and HflK could regulate a protease. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.471 |
AMG52647.1 | yajC | AL524_05895 | AL524_20895 | Protease modulator HflC; HflC and HflK could regulate a protease. | Preprotein translocase subunit YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.531 |
AMG52647.1 | yidC | AL524_05895 | AL524_03015 | Protease modulator HflC; HflC and HflK could regulate a protease. | Membrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.567 |