STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoT1spoT-like ppGpp hydrolase. (201 aa)    
Predicted Functional Partners:
gppA
Transposase and inactivated derivative.
  
 
 0.907
gmpk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
 
 0.906
ndk
Transposase and inactivated derivative; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.902
spoT33
spoT-like ppGpp synthetase.
  
     0.756
nrdA
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
     
  0.650
nrdB
Ribonucleoside-diphosphate reductase beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family.
     
  0.650
dsbA
Thiol:disulfide interchange protein.
   
 
 0.556
rpmE
50S ribosomal protein L31; Belongs to the bacterial ribosomal protein bL31 family.
  
   0.513
tnE
Conjugative transfer protein.
       0.506
ptrB
Protease II.
      
 0.505
Your Current Organism:
Orientia tsutsugamushi
NCBI taxonomy Id: 357244
Other names: O. tsutsugamushi str. Boryong, Orientia tsutsugamushi Boryong, Orientia tsutsugamushi str. Boryong, Orientia tsutsugamushi strain Boryong
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.