STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmpkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (221 aa)    
Predicted Functional Partners:
rpoZ
Hypothetical protein.
  
  
 0.987
spoT15
spoT-like ppGpp hydrolase.
  
 
 0.951
ndk
Transposase and inactivated derivative; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.946
nrdA
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
    
 0.917
spoT21
spoT-like bifunctional ppGpp synthetase/hydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.913
spoT1
spoT-like ppGpp hydrolase.
  
 
 0.906
spoT2
spoT-like ppGpp hydrolase.
  
 
 0.906
spoT7
Replicative DNA helicase.
  
 
 0.906
spoT11
Replicative DNA helicase.
  
 
 0.906
spoT18
spoT-like ppGpp hydrolase.
  
 
 0.906
Your Current Organism:
Orientia tsutsugamushi
NCBI taxonomy Id: 357244
Other names: O. tsutsugamushi str. Boryong, Orientia tsutsugamushi Boryong, Orientia tsutsugamushi str. Boryong, Orientia tsutsugamushi strain Boryong
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