STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
PAC1Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs. (460 aa)    
Predicted Functional Partners:
MPH_10774
ATPase AAA+ type core.
    
 0.995
MPH_07601
NUDE protein.
    
 
 0.953
MPH_00718
WD_REPEATS_REGION domain-containing protein.
   
 0.947
MPH_07380
CS domain-containing protein.
    
 0.944
MPH_04650
CAP-Gly domain-containing protein.
    
 0.943
MPH_00653
Dynamitin subunit 2.
    
 0.925
MPH_04547
Uncharacterized protein.
    
 0.915
MPH_04286
Dynein light chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.
    
 0.907
MPH_04502
Platelet-activating factor acetylhydrolase plasma/intracellular isoform II.
     
 0.892
MPH_07691
Dynein 1 light intermediate chain.
   
 0.870
Your Current Organism:
Macrophomina phaseolina
NCBI taxonomy Id: 1126212
Other names: M. phaseolina MS6, Macrophomina phaseolina MS6, Macrophomina phaseolina str. MS6, Macrophomina phaseolina strain MS6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.