kduI protein (Lactobacillus parabrevis) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

kduI

5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family. (281 aa)

Predicted Functional Partners:

KRO05397.1

0.943

KRO06800.1

0.841

uxuA

0.785

KRO05896.1

0.768

KRO06255.1

0.623

KRO06282.1

0.623

KRO06532.1

0.623

KRO06557.1

0.623

KRO04627.1

0.517

KRO06507.1

0.503

Your Current Organism:

Lactobacillus parabrevis

NCBI taxonomy Id: 357278
Other names: ATCC 53295, L. parabrevis, LMG 11984, LMG:11984, Lactobacillus parabrevis Vancanneyt et al. 2006

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRO04627.1	kduI	IV61_GL001967	IV61_GL000712	Hypothetical protein; Belongs to the glycosyl hydrolase 28 family.	5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.	0.517
KRO05397.1	KRO05896.1	IV61_GL001332	IV61_GL000710	2-deoxy-D-gluconate 3-dehydrogenase.	2-dehydro-3-deoxygluconokinase.	0.929
KRO05397.1	KRO06255.1	IV61_GL001332	IV61_GL000286	2-deoxy-D-gluconate 3-dehydrogenase.	Short-chain alcohol dehydrogenase.	0.462
KRO05397.1	KRO06532.1	IV61_GL001332	IV61_GL002248	2-deoxy-D-gluconate 3-dehydrogenase.	Short-chain alcohol dehydrogenase.	0.457
KRO05397.1	KRO06557.1	IV61_GL001332	IV61_GL002274	2-deoxy-D-gluconate 3-dehydrogenase.	3-oxoacyl-ACP reductase.	0.459
KRO05397.1	kduI	IV61_GL001332	IV61_GL000712	2-deoxy-D-gluconate 3-dehydrogenase.	5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.	0.943
KRO05397.1	uxuA	IV61_GL001332	IV61_GL000711	2-deoxy-D-gluconate 3-dehydrogenase.	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.	0.874
KRO05896.1	KRO05397.1	IV61_GL000710	IV61_GL001332	2-dehydro-3-deoxygluconokinase.	2-deoxy-D-gluconate 3-dehydrogenase.	0.929
KRO05896.1	KRO06255.1	IV61_GL000710	IV61_GL000286	2-dehydro-3-deoxygluconokinase.	Short-chain alcohol dehydrogenase.	0.655
KRO05896.1	KRO06282.1	IV61_GL000710	IV61_GL000314	2-dehydro-3-deoxygluconokinase.	Oxidoreductase, short chain dehydrogenase reductase family protein.	0.655
KRO05896.1	KRO06532.1	IV61_GL000710	IV61_GL002248	2-dehydro-3-deoxygluconokinase.	Short-chain alcohol dehydrogenase.	0.655
KRO05896.1	KRO06557.1	IV61_GL000710	IV61_GL002274	2-dehydro-3-deoxygluconokinase.	3-oxoacyl-ACP reductase.	0.655
KRO05896.1	KRO06800.1	IV61_GL000710	IV61_GL001889	2-dehydro-3-deoxygluconokinase.	3-ketoacyl-ACP reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.882
KRO05896.1	kduI	IV61_GL000710	IV61_GL000712	2-dehydro-3-deoxygluconokinase.	5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.	0.768
KRO05896.1	uxuA	IV61_GL000710	IV61_GL000711	2-dehydro-3-deoxygluconokinase.	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.	0.994
KRO06255.1	KRO05397.1	IV61_GL000286	IV61_GL001332	Short-chain alcohol dehydrogenase.	2-deoxy-D-gluconate 3-dehydrogenase.	0.462
KRO06255.1	KRO05896.1	IV61_GL000286	IV61_GL000710	Short-chain alcohol dehydrogenase.	2-dehydro-3-deoxygluconokinase.	0.655
KRO06255.1	KRO06800.1	IV61_GL000286	IV61_GL001889	Short-chain alcohol dehydrogenase.	3-ketoacyl-ACP reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.496
KRO06255.1	kduI	IV61_GL000286	IV61_GL000712	Short-chain alcohol dehydrogenase.	5-keto-4-deoxyuronate isomerase; Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. Belongs to the KduI family.	0.623
KRO06255.1	uxuA	IV61_GL000286	IV61_GL000711	Short-chain alcohol dehydrogenase.	Mannonate dehydratase; Catalyzes the dehydration of D-mannonate.	0.645

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Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

20

PPI enrichment p-value:

2.86e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 62

1.51

1.91

6.21e-06

GO:0000160

Phosphorelay signal transduction system

5 of 52

1.51

1.66

5.65e-05

GO:0050794

Regulation of cellular process

9 of 253

1.08

1.24

2.38e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

5 of 25

1.83

2.27

8.43e-06

GO:0000155

Phosphorelay sensor kinase activity

4 of 24

1.75

1.79

0.00011

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 171

1.14

1.22

2.82e-05

GO:0016740

Transferase activity

9 of 591

0.71

0.61

0.00028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 579

0.61

0.36

0.0471

GO:0016021

Integral component of membrane

8 of 769

0.54

0.33

0.0471

GO:0016020

Membrane

9 of 1176

0.41

0.28

0.0471

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2148

Phosphorelay signal transduction system, and RNA polymerase sigma factor 54 interaction domain

11 of 41

1.96

6.07

1.09e-18

CL:2155

Mixed, incl. PAS domain, and Phosphoric diester hydrolase activity

8 of 21

2.11

5.5

6.46e-14

CL:2161

PAS-associated, C-terminal, and Bacterial chemotaxis

6 of 10

2.31

4.88

6.39e-11

CL:2163

Diguanylate cyclase, and Regulation of signaling

3 of 5

2.31

2.21

5.90e-05

CL:2215

Sigma-54 interaction domain, ATP-binding site 1, and PAS fold

3 of 7

2.16

2.01

0.00012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 277

1.08

1.42

8.29e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

4 of 74

1.26

0.79

0.0122

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001610

PAC motif

4 of 8

2.23

2.3

3.24e-05

IPR035965

PAS domain superfamily

4 of 10

2.13

2.26

3.27e-05

IPR000014

PAS domain

4 of 10

2.13

2.26

3.27e-05

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

4 of 17

1.9

1.92

9.67e-05

IPR005467

Histidine kinase domain

4 of 20

1.83

1.81

0.00014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

4 of 9

2.17

2.71

3.74e-06

SM00091

PAS domain

4 of 11

2.09

2.64

3.74e-06

SM00388

His Kinase A (phosphoacceptor) domain

4 of 17

1.9

2.31

1.03e-05

SM00387

Histidine kinase-like ATPases

4 of 22

1.79

2.1

1.92e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

2 of 5

2.13

1.25

0.0042

(more ...)

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