STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
fumCFumarase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (469 aa)    
Predicted Functional Partners:
SFR30803.1
Succinate dehydrogenase / fumarate reductase flavoprotein subunit.
 0.998
SFR30802.1
Succinate dehydrogenase / fumarate reductase iron-sulfur subunit.
  
 0.980
SFR30270.1
Malate dehydrogenase (NAD); Belongs to the LDH/MDH superfamily.
  
 0.978
SFR30800.1
Succinate dehydrogenase subunit C.
   
 
 0.967
SFR39200.1
Citrate synthase.
   
 0.960
SFR60734.1
Allosteric NADP-dependent malic enzyme.
  
 
 0.952
SFR30801.1
Succinate dehydrogenase subunit D.
   
 
 0.937
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.923
SFR59325.1
Succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
    
 0.916
argH
Argininosuccinate lyase.
   
 
0.909
Your Current Organism:
Halorubrum sodomense
NCBI taxonomy Id: 35743
Other names: ATCC 33755, CIP 105330, DSM 3755, H. sodomense, Halobacterium sodomense, Halobacterium sodomitanum, Halobacterium sodomiticum, Halorubrobacterium sodomense, IFO 14740, JCM 8880, NBRC 14740, NCIMB 2197, strain RD-26
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