SFR50807.1 protein (Halorubrum sodomense) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SFR50807.1

Cysteine synthase A. (305 aa)

Predicted Functional Partners:

SFR60580.1

0.966

cysS

0.940

SFR33178.1

0.835

SFR43906.1

0.833

SFR51189.1

0.833

SFR50797.1

0.778

ahcY

0.759

SFR33147.1

0.734

SFR36313.1

0.734

SFR37780.1

0.734

Your Current Organism:

Halorubrum sodomense

NCBI taxonomy Id: 35743
Other names: ATCC 33755, CIP 105330, DSM 3755, H. sodomense, Halobacterium sodomense, Halobacterium sodomitanum, Halobacterium sodomiticum, Halorubrobacterium sodomense, IFO 14740, JCM 8880, NBRC 14740, NCIMB 2197, strain RD-26

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFR33147.1	SFR36313.1	SAMN04487937_1168	SAMN04487937_1534	Glyoxylase, beta-lactamase superfamily II.	Glyoxylase, beta-lactamase superfamily II.	0.762
SFR33147.1	SFR37780.1	SAMN04487937_1168	SAMN04487937_1672	Glyoxylase, beta-lactamase superfamily II.	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	0.772
SFR33147.1	SFR43906.1	SAMN04487937_1168	SAMN04487937_1918	Glyoxylase, beta-lactamase superfamily II.	Aspartate aminotransferase.	0.715
SFR33147.1	SFR50807.1	SAMN04487937_1168	SAMN04487937_2563	Glyoxylase, beta-lactamase superfamily II.	Cysteine synthase A.	0.734
SFR33147.1	SFR51189.1	SAMN04487937_1168	SAMN04487937_2591	Glyoxylase, beta-lactamase superfamily II.	Aspartate aminotransferase.	0.715
SFR33147.1	SFR60580.1	SAMN04487937_1168	SAMN04487937_3048	Glyoxylase, beta-lactamase superfamily II.	Cystathionine beta-lyase/cystathionine gamma-synthase.	0.420
SFR33178.1	SFR50807.1	SAMN04487937_1172	SAMN04487937_2563	Sulfide:quinone oxidoreductase.	Cysteine synthase A.	0.835
SFR33178.1	SFR60580.1	SAMN04487937_1172	SAMN04487937_3048	Sulfide:quinone oxidoreductase.	Cystathionine beta-lyase/cystathionine gamma-synthase.	0.512
SFR36313.1	SFR33147.1	SAMN04487937_1534	SAMN04487937_1168	Glyoxylase, beta-lactamase superfamily II.	Glyoxylase, beta-lactamase superfamily II.	0.762
SFR36313.1	SFR37780.1	SAMN04487937_1534	SAMN04487937_1672	Glyoxylase, beta-lactamase superfamily II.	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	0.766
SFR36313.1	SFR43906.1	SAMN04487937_1534	SAMN04487937_1918	Glyoxylase, beta-lactamase superfamily II.	Aspartate aminotransferase.	0.715
SFR36313.1	SFR50807.1	SAMN04487937_1534	SAMN04487937_2563	Glyoxylase, beta-lactamase superfamily II.	Cysteine synthase A.	0.734
SFR36313.1	SFR51189.1	SAMN04487937_1534	SAMN04487937_2591	Glyoxylase, beta-lactamase superfamily II.	Aspartate aminotransferase.	0.715
SFR37780.1	SFR33147.1	SAMN04487937_1672	SAMN04487937_1168	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	Glyoxylase, beta-lactamase superfamily II.	0.772
SFR37780.1	SFR36313.1	SAMN04487937_1672	SAMN04487937_1534	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	Glyoxylase, beta-lactamase superfamily II.	0.766
SFR37780.1	SFR43906.1	SAMN04487937_1672	SAMN04487937_1918	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	Aspartate aminotransferase.	0.715
SFR37780.1	SFR50807.1	SAMN04487937_1672	SAMN04487937_2563	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	Cysteine synthase A.	0.734
SFR37780.1	SFR51189.1	SAMN04487937_1672	SAMN04487937_2591	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	Aspartate aminotransferase.	0.715
SFR37780.1	SFR60580.1	SAMN04487937_1672	SAMN04487937_3048	Thiosulfate/3-mercaptopyruvate sulfurtransferase.	Cystathionine beta-lyase/cystathionine gamma-synthase.	0.422
SFR43906.1	SFR33147.1	SAMN04487937_1918	SAMN04487937_1168	Aspartate aminotransferase.	Glyoxylase, beta-lactamase superfamily II.	0.715

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

3.55e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1901071

Glucosamine-containing compound metabolic process

4 of 58

1.88

1.54

0.00073

GO:0034221

Fungal-type cell wall chitin biosynthetic process

2 of 3

2.87

1.13

0.0092

GO:0006048

UDP-N-acetylglucosamine biosynthetic process

2 of 4

2.74

1.1

0.0103

GO:0006046

N-acetylglucosamine catabolic process

2 of 4

2.74

1.1

0.0103

GO:0006596

Polyamine biosynthetic process

2 of 5

2.64

1.09

0.0103

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0047419

N-acetylgalactosamine-6-phosphate deacetylase activity

2 of 2

3.04

1.19

0.0073

GO:0008448

N-acetylglucosamine-6-phosphate deacetylase activity

2 of 2

3.04

1.19

0.0073

GO:0003824

Catalytic activity

11 of 5072

0.38

0.27

0.0382

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15182

Synthesis of UDP-N-acetyl-glucosamine, and Glucosamine catabolic process

5 of 8

2.84

4.94

5.87e-10

CL:18181

Melatonin metabolic process, and Staurosporine biosynthesis

3 of 5

2.82

2.66

1.34e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

5 of 153

1.56

1.82

2.37e-05

map01100

Metabolic pathways

11 of 3788

0.5

0.43

0.00022

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446210

Synthesis of UDP-N-acetyl-glucosamine

5 of 7

2.9

5.26

1.58e-10

MAP-446219

Synthesis of substrates in N-glycan biosythesis

5 of 22

2.4

4.09

7.99e-09

MAP-446193

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

5 of 38

2.16

3.46

6.31e-08

MAP-446203

Asparagine N-linked glycosylation

5 of 161

1.53

1.71

4.62e-05

MAP-351202

Metabolism of polyamines

2 of 14

2.2

0.96

0.0168

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003764

N-acetylglucosamine-6-phosphate deacetylase

2 of 2

3.04

1.04

0.0136

IPR017932

Glutamine amidotransferase type 2 domain

2 of 6

2.56

0.83

0.0316

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