STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
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[Homology]
Score
Ping_0066Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...] (177 aa)    
Predicted Functional Partners:
rpoE
RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: pha:PSHAa0726 sigma E (sigma 24) factor of RNA polymerase, response to periplasmic stress (TetR/ArcR) (partial match); Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.997
Ping_0067
PFAM: MucB/RseB family protein; KEGG: cps:CPS_4127 sigma-E factor regulatory protein RseB.
 
 
 0.997
rseC
PFAM: Positive regulator of sigma(E), RseC/MucC; KEGG: shm:Shewmr7_2933 positive regulator of sigma E, RseC/MucC.
 
  
 0.923
Ping_0995
RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: vfi:VFA0766 RNA polymerase sigma-E factor homologue; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.918
Ping_1037
TIGRFAM: protease Do; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: sde:Sde_3731 protease DO; Belongs to the peptidase S1C family.
  
 
 0.901
Ping_2880
DegS peptidase, Serine peptidase, MEROPS family S01B; TIGRFAM: periplasmic serine protease DegS; PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein; KEGG: vvu:VV10604 protease DegS.
  
 
 0.901
Ping_0946
RNA polymerase, sigma-24 subunit, ECF subfamily protein; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: pha:PSHAa0959 RNA polymerase sigma-70 factor; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.859
Ping_2870
PFAM: Stringent starvation protein B; KEGG: vfi:VF2215 stringent starvation protein B.
    
 
 0.857
Ping_0947
KEGG: ppr:PBPRA0959 hypothetical protein.
  
 
 0.831
rraB
Hypothetical protein DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
   
 0.768
Your Current Organism:
Psychromonas ingrahamii
NCBI taxonomy Id: 357804
Other names: P. ingrahamii 37, Psychromonas ingrahamii 37, Psychromonas ingrahamii str. 37, Psychromonas ingrahamii strain 37, gas vacuolate str. 37
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