STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ping_0067PFAM: MucB/RseB family protein; KEGG: cps:CPS_4127 sigma-E factor regulatory protein RseB. (335 aa)    
Predicted Functional Partners:
Ping_0066
Anti sigma-E protein, RseA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish [...]
 
 
 0.997
rseC
PFAM: Positive regulator of sigma(E), RseC/MucC; KEGG: shm:Shewmr7_2933 positive regulator of sigma E, RseC/MucC.
 
  
 0.997
rpoE
RNA polymerase, sigma-24 subunit, RpoE; PFAM: sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2; KEGG: pha:PSHAa0726 sigma E (sigma 24) factor of RNA polymerase, response to periplasmic stress (TetR/ArcR) (partial match); Belongs to the sigma-70 factor family. ECF subfamily.
 
 0.951
Ping_0497
PFAM: Methyltransferase type 11; KEGG: pha:PSHAa1965 S-adenosyl-L-methionine-dependent methyltransferase.
  
     0.735
Ping_2210
Protein containing tetratricopeptide (TPR) repeat; May be involved in cell division.
  
   
 0.583
recO
DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
    0.576
rraB
Hypothetical protein DUF1260; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.551
seqA
Negative regulator of replication initiation SeqA; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.545
Ping_3156
Thiol:disulfide interchange protein DsbA; PFAM: DSBA oxidoreductase; KEGG: vvu:VV11036 thiol-disulfide isomerase and thioredoxins.
  
     0.531
Ping_3310
PFAM: protein of unknown function DUF412; KEGG: yps:YPTB2595 hypothetical protein.
  
     0.527
Your Current Organism:
Psychromonas ingrahamii
NCBI taxonomy Id: 357804
Other names: P. ingrahamii 37, Psychromonas ingrahamii 37, Psychromonas ingrahamii str. 37, Psychromonas ingrahamii strain 37, gas vacuolate str. 37
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