| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ping_0567 | Ping_3407 | Ping_0567 | Ping_3407 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | PFAM: Rhodanese domain protein; KEGG: pat:Patl_0964 rhodanese-like; Belongs to the UPF0176 family. | 0.885 |
| Ping_0567 | hepA | Ping_0567 | Ping_0568 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | RNA polymerase-associated protein HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | 0.869 |
| Ping_0567 | mnmE | Ping_0567 | Ping_3612 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | 0.586 |
| Ping_0567 | rplC | Ping_0567 | Ping_3524 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.526 |
| Ping_0567 | rplM | Ping_0567 | Ping_2877 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.522 |
| Ping_0567 | rplO | Ping_0567 | Ping_3505 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.528 |
| Ping_0567 | rplU | Ping_0567 | Ping_0525 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.600 |
| Ping_0567 | rsfS | Ping_0567 | Ping_1137 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.569 |
| Ping_0567 | truB | Ping_0567 | Ping_0819 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.590 |
| Ping_0567 | truD | Ping_0567 | Ping_0674 | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | Pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. | 0.629 |
| Ping_3407 | Ping_0567 | Ping_3407 | Ping_0567 | PFAM: Rhodanese domain protein; KEGG: pat:Patl_0964 rhodanese-like; Belongs to the UPF0176 family. | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | 0.885 |
| hepA | Ping_0567 | Ping_0568 | Ping_0567 | RNA polymerase-associated protein HepA; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | 0.869 |
| mnmE | Ping_0567 | Ping_3612 | Ping_0567 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | PFAM: pseudouridine synthase; KEGG: ppr:PBPRA0408 putative ribosomal large subunit pseudouridine synthase A. | 0.586 |
| mnmE | rplC | Ping_3612 | Ping_3524 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | LSU ribosomal protein L3P; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | 0.685 |
| mnmE | rplM | Ping_3612 | Ping_2877 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | LSU ribosomal protein L13P; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | 0.761 |
| mnmE | rplO | Ping_3612 | Ping_3505 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | LSU ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. | 0.761 |
| mnmE | rplU | Ping_3612 | Ping_0525 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | LSU ribosomal protein L21P; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.771 |
| mnmE | rsfS | Ping_3612 | Ping_1137 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Iojap-like protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.766 |
| mnmE | truB | Ping_3612 | Ping_0819 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. | 0.682 |
| mnmE | truD | Ping_3612 | Ping_0674 | tRNA modification GTPase trmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. | Pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. | 0.764 |