node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ping_0060 | dcd | Ping_0060 | Ping_0756 | Methionine repressor, MetJ; This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.518 |
Ping_0665 | Ping_0740 | Ping_0665 | Ping_0740 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | 0.900 |
Ping_0665 | dcd | Ping_0665 | Ping_0756 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.917 |
Ping_0665 | ndk | Ping_0665 | Ping_3326 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.900 |
Ping_0665 | pyrG | Ping_0665 | Ping_0668 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.926 |
Ping_0665 | thyA | Ping_0665 | Ping_0506 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.603 |
Ping_0665 | udk | Ping_0665 | Ping_1489 | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | KEGG: son:SO2617 uridine kinase; TIGRFAM: uridine kinase; PFAM: phosphoribulokinase/uridine kinase. | 0.901 |
Ping_0740 | Ping_0665 | Ping_0740 | Ping_0665 | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | TIGRFAM: MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase; KEGG: ppr:PBPRA3081 putative MazG protein. | 0.900 |
Ping_0740 | Ping_1109 | Ping_0740 | Ping_1109 | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | PFAM: ribonucleotide reductase; KEGG: spt:SPA0586 ribonucleoside-diphosphate reductase 1 beta chain. | 0.410 |
Ping_0740 | dcd | Ping_0740 | Ping_0756 | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.901 |
Ping_0740 | dut | Ping_0740 | Ping_0058 | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.917 |
Ping_0740 | ndk | Ping_0740 | Ping_3326 | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.910 |
Ping_0740 | pyrG | Ping_0740 | Ping_0668 | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.906 |
Ping_1109 | Ping_0740 | Ping_1109 | Ping_0740 | PFAM: ribonucleotide reductase; KEGG: spt:SPA0586 ribonucleoside-diphosphate reductase 1 beta chain. | Ribonucleoside-triphosphate reductase class III catalytic subunit; KEGG: sec:SC4307 anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: formate C-acetyltransferase glycine radical; ATP-cone domain protein. | 0.410 |
Ping_1109 | Ping_1112 | Ping_1109 | Ping_1112 | PFAM: ribonucleotide reductase; KEGG: spt:SPA0586 ribonucleoside-diphosphate reductase 1 beta chain. | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
Ping_1109 | dcd | Ping_1109 | Ping_0756 | PFAM: ribonucleotide reductase; KEGG: spt:SPA0586 ribonucleoside-diphosphate reductase 1 beta chain. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.543 |
Ping_1109 | ndk | Ping_1109 | Ping_3326 | PFAM: ribonucleotide reductase; KEGG: spt:SPA0586 ribonucleoside-diphosphate reductase 1 beta chain. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.918 |
Ping_1112 | Ping_1109 | Ping_1112 | Ping_1109 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | PFAM: ribonucleotide reductase; KEGG: spt:SPA0586 ribonucleoside-diphosphate reductase 1 beta chain. | 0.999 |
Ping_1112 | dcd | Ping_1112 | Ping_0756 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | 0.659 |
Ping_1112 | dut | Ping_1112 | Ping_0058 | Ribonucleoside-diphosphate reductase class Ia alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.788 |