| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ping_0113 | Ping_1488 | Ping_0113 | Ping_1488 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: vch:VC1498 GAF domain-containing protein. | 0.900 |
| Ping_0113 | Ping_1976 | Ping_0113 | Ping_1976 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: aminotransferase, class I and II; KEGG: vpa:VP1900 aspartate aminotransferase. | 0.924 |
| Ping_0113 | Ping_3644 | Ping_0113 | Ping_3644 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: cps:CPS_2546 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | 0.963 |
| Ping_0113 | metE | Ping_0113 | Ping_3386 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.984 |
| Ping_0113 | metK | Ping_0113 | Ping_3227 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.968 |
| Ping_0113 | msrA-2 | Ping_0113 | Ping_1447 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.417 |
| Ping_0233 | Ping_1488 | Ping_0233 | Ping_1488 | KEGG: shm:Shewmr7_0037 carbonic anhydrase, family 3. | KEGG: vch:VC1498 GAF domain-containing protein. | 0.503 |
| Ping_1488 | Ping_0113 | Ping_1488 | Ping_0113 | KEGG: vch:VC1498 GAF domain-containing protein. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.900 |
| Ping_1488 | Ping_0233 | Ping_1488 | Ping_0233 | KEGG: vch:VC1498 GAF domain-containing protein. | KEGG: shm:Shewmr7_0037 carbonic anhydrase, family 3. | 0.503 |
| Ping_1488 | Ping_1976 | Ping_1488 | Ping_1976 | KEGG: vch:VC1498 GAF domain-containing protein. | PFAM: aminotransferase, class I and II; KEGG: vpa:VP1900 aspartate aminotransferase. | 0.906 |
| Ping_1488 | Ping_3241 | Ping_1488 | Ping_3241 | KEGG: vch:VC1498 GAF domain-containing protein. | N-acetylmuramoyl-L-alanine amidase; PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: ppr:PBPRA3353 putative N-acetylmuramoyl-L-alanine amidase. | 0.546 |
| Ping_1488 | Ping_3264 | Ping_1488 | Ping_3264 | KEGG: vch:VC1498 GAF domain-containing protein. | PFAM: protein of unknown function DUF152; KEGG: vch:VC0710 conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.542 |
| Ping_1488 | Ping_3644 | Ping_1488 | Ping_3644 | KEGG: vch:VC1498 GAF domain-containing protein. | KEGG: cps:CPS_2546 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | 0.900 |
| Ping_1488 | metE | Ping_1488 | Ping_3386 | KEGG: vch:VC1498 GAF domain-containing protein. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.900 |
| Ping_1488 | metK | Ping_1488 | Ping_3227 | KEGG: vch:VC1498 GAF domain-containing protein. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
| Ping_1488 | msrA-2 | Ping_1488 | Ping_1447 | KEGG: vch:VC1498 GAF domain-containing protein. | Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. | 0.602 |
| Ping_1488 | proQ | Ping_1488 | Ping_2188 | KEGG: vch:VC1498 GAF domain-containing protein. | ProQ activator of osmoprotectant transporter ProP; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. | 0.764 |
| Ping_1976 | Ping_0113 | Ping_1976 | Ping_0113 | PFAM: aminotransferase, class I and II; KEGG: vpa:VP1900 aspartate aminotransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.924 |
| Ping_1976 | Ping_1488 | Ping_1976 | Ping_1488 | PFAM: aminotransferase, class I and II; KEGG: vpa:VP1900 aspartate aminotransferase. | KEGG: vch:VC1498 GAF domain-containing protein. | 0.906 |
| Ping_1976 | Ping_3644 | Ping_1976 | Ping_3644 | PFAM: aminotransferase, class I and II; KEGG: vpa:VP1900 aspartate aminotransferase. | KEGG: cps:CPS_2546 O-acetylhomoserine/O-acetylserine sulfhydrylase; TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | 0.900 |