node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ping_3045 | guaA | Ping_3045 | Ping_2949 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.970 |
Ping_3045 | guaB | Ping_3045 | Ping_2950 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.945 |
Ping_3045 | surE | Ping_3045 | Ping_0675 | Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
apt | gmk | Ping_2278 | Ping_3623 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.961 |
apt | guaA | Ping_2278 | Ping_2949 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.988 |
apt | guaB | Ping_2278 | Ping_2950 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.419 |
apt | purL | Ping_2278 | Ping_3318 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.784 |
apt | pyrG | Ping_2278 | Ping_0668 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.475 |
apt | surE | Ping_2278 | Ping_0675 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'-nucleotidase / 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.917 |
apt | upp | Ping_2278 | Ping_1628 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.421 |
argS | gmk | Ping_0006 | Ping_3623 | KEGG: sfr:Sfri_3762 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.678 |
argS | guaA | Ping_0006 | Ping_2949 | KEGG: sfr:Sfri_3762 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.944 |
argS | lysS | Ping_0006 | Ping_3428 | KEGG: sfr:Sfri_3762 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: plu:plu3548 lysyl-tRNA synthetase (lysine--tRNA ligase); Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.933 |
argS | purL | Ping_0006 | Ping_3318 | KEGG: sfr:Sfri_3762 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.612 |
argS | pyrG | Ping_0006 | Ping_0668 | KEGG: sfr:Sfri_3762 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.804 |
gmk | apt | Ping_3623 | Ping_2278 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.961 |
gmk | argS | Ping_3623 | Ping_0006 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | KEGG: sfr:Sfri_3762 arginyl-tRNA synthetase; TIGRFAM: arginyl-tRNA synthetase. | 0.678 |
gmk | guaA | Ping_3623 | Ping_2949 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.966 |
gmk | guaB | Ping_3623 | Ping_2950 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.454 |
gmk | lysS | Ping_3623 | Ping_3428 | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | TIGRFAM: lysyl-tRNA synthetase; PFAM: tRNA synthetase, class II (D, K and N); nucleic acid binding, OB-fold, tRNA/helicase-type; KEGG: plu:plu3548 lysyl-tRNA synthetase (lysine--tRNA ligase); Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.461 |