node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABQ88486.1 | fhs | RoseRS_0043 | RoseRS_0219 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.572 |
ABQ88486.1 | folD | RoseRS_0043 | RoseRS_4392 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.861 |
ABQ88486.1 | glyA | RoseRS_0043 | RoseRS_0389 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.873 |
ABQ88486.1 | purA | RoseRS_0043 | RoseRS_4214 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.990 |
ABQ88486.1 | purH | RoseRS_0043 | RoseRS_0206 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.991 |
ABQ88486.1 | purN | RoseRS_0043 | RoseRS_2693 | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.902 |
ABQ90417.1 | fhs | RoseRS_2032 | RoseRS_0219 | PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.518 |
ABQ90417.1 | folD | RoseRS_2032 | RoseRS_4392 | PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.936 |
ABQ90417.1 | gcvT | RoseRS_2032 | RoseRS_1526 | PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.927 |
ABQ90417.1 | glyA | RoseRS_2032 | RoseRS_0389 | PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.953 |
ABQ92906.1 | fhs | RoseRS_4575 | RoseRS_0219 | PFAM: Formiminotransferase-cyclodeaminase. | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | 0.948 |
ABQ92906.1 | fmt | RoseRS_4575 | RoseRS_3920 | PFAM: Formiminotransferase-cyclodeaminase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.916 |
ABQ92906.1 | folD | RoseRS_4575 | RoseRS_4392 | PFAM: Formiminotransferase-cyclodeaminase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.944 |
ABQ92906.1 | gcvT | RoseRS_4575 | RoseRS_1526 | PFAM: Formiminotransferase-cyclodeaminase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.931 |
ABQ92906.1 | purH | RoseRS_4575 | RoseRS_0206 | PFAM: Formiminotransferase-cyclodeaminase. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme, formylation region. | 0.910 |
ABQ92906.1 | purN | RoseRS_4575 | RoseRS_2693 | PFAM: Formiminotransferase-cyclodeaminase. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.914 |
fhs | ABQ88486.1 | RoseRS_0219 | RoseRS_0043 | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | TIGRFAM: adenylosuccinate lyase; PFAM: fumarate lyase; Adenylosuccinate lyase C-terminal domain protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.572 |
fhs | ABQ90417.1 | RoseRS_0219 | RoseRS_2032 | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.518 |
fhs | ABQ92906.1 | RoseRS_0219 | RoseRS_4575 | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | PFAM: Formiminotransferase-cyclodeaminase. | 0.948 |
fhs | folD | RoseRS_0219 | RoseRS_4392 | PFAM: formate-tetrahydrofolate ligase, FTHFS; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.995 |