STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cphy_0286methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (175 aa)    
Predicted Functional Partners:
Cphy_0820
KEGG: cbf:CLI_1135 hypothetical protein.
      0.827
Cphy_2044
PFAM: domain of unknown function DUF1730; KEGG: cpf:CPF_1527 putative iron-sulfur cluster-binding protein.
      0.706
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 
 
 0.626
Cphy_0287
PFAM: GCN5-related N-acetyltransferase; KEGG: lsl:LSL_0634 phosphinothricin N-acetyltransferase.
       0.556
Cphy_1745
KEGG: lpf:lpl1156 methylated-DNA-[protein]-cysteine S-methyltransferase; TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: Ada metal-binding domain protein; Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding; SMART: helix-turn-helix- domain containing protein AraC type.
 
  
0.547
Cphy_1099
KEGG: cbe:Cbei_2796 Mug G:T/U mismatch-specific DNA glycosylase.
 
  
 0.532
Cphy_0502
PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; KEGG: chy:CHY_2201 ATPase, AAA family.
 
     0.424
Cphy_0285
PFAM: histidine kinase HAMP region domain protein; chemotaxis sensory transducer; KEGG: cbe:Cbei_4017 methyl-accepting chemotaxis sensory transducer.
       0.410
hisI
TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; KEGG: cth:Cthe_2889 phosphoribosyl-AMP cyclohydrolase; In the C-terminal section; belongs to the PRA-PH family.
     
 0.400
Your Current Organism:
Lachnoclostridium phytofermentans
NCBI taxonomy Id: 357809
Other names: Clostridium phytofermentans ISDg, L. phytofermentans ISDg, Lachnoclostridium phytofermentans ISDg
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