| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cphy_0693 | mprF | Cphy_0693 | Cphy_1959 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: bfr:BF1755 hypothetical protein. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.536 |
| Cphy_1379 | mprF | Cphy_1379 | Cphy_1959 | TIGRFAM: precorrin-6x reductase; precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Precorrin-6x reductase CbiJ/CobK; KEGG: ctc:CTC00734 precorrin-6B methylase/decarboxylase cbiT/cbiE. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.470 |
| Cphy_1534 | mprF | Cphy_1534 | Cphy_1959 | PFAM: Endonuclease/exonuclease/phosphatase; KEGG: lca:LSEI_2779 metal-dependent hydrolase. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.414 |
| Cphy_1743 | Cphy_2202 | Cphy_1743 | Cphy_2202 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Acetoacetate decarboxylase; KEGG: cac:CAC1044 NADH:flavin oxidoreductase, possible NADH oxidase. | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | 0.574 |
| Cphy_1743 | mprF | Cphy_1743 | Cphy_1959 | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Acetoacetate decarboxylase; KEGG: cac:CAC1044 NADH:flavin oxidoreductase, possible NADH oxidase. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.414 |
| Cphy_1958 | Cphy_1960 | Cphy_1958 | Cphy_1960 | PFAM: Mg2 transporter protein CorA family protein; KEGG: tde:TDE1034 magnesium and cobalt transporter, putative. | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | 0.473 |
| Cphy_1958 | mprF | Cphy_1958 | Cphy_1959 | PFAM: Mg2 transporter protein CorA family protein; KEGG: tde:TDE1034 magnesium and cobalt transporter, putative. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.518 |
| Cphy_1960 | Cphy_1958 | Cphy_1960 | Cphy_1958 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | PFAM: Mg2 transporter protein CorA family protein; KEGG: tde:TDE1034 magnesium and cobalt transporter, putative. | 0.473 |
| Cphy_1960 | Cphy_1961 | Cphy_1960 | Cphy_1961 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | PFAM: phosphatidylserine decarboxylase-related; KEGG: cac:CAC0799 phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family. | 0.995 |
| Cphy_1960 | Cphy_1962 | Cphy_1960 | Cphy_1962 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit. | 0.452 |
| Cphy_1960 | mprF | Cphy_1960 | Cphy_1959 | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.882 |
| Cphy_1961 | Cphy_1960 | Cphy_1961 | Cphy_1960 | PFAM: phosphatidylserine decarboxylase-related; KEGG: cac:CAC0799 phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family. | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | 0.995 |
| Cphy_1961 | Cphy_1962 | Cphy_1961 | Cphy_1962 | PFAM: phosphatidylserine decarboxylase-related; KEGG: cac:CAC0799 phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family. | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit. | 0.665 |
| Cphy_1961 | mprF | Cphy_1961 | Cphy_1959 | PFAM: phosphatidylserine decarboxylase-related; KEGG: cac:CAC0799 phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.710 |
| Cphy_1962 | Cphy_1960 | Cphy_1962 | Cphy_1960 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit. | PFAM: CDP-alcohol phosphatidyltransferase; KEGG: cac:CAC0798 phosphatidylserine synthase. | 0.452 |
| Cphy_1962 | Cphy_1961 | Cphy_1962 | Cphy_1961 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit. | PFAM: phosphatidylserine decarboxylase-related; KEGG: cac:CAC0799 phosphatidylserine decarboxylase; Belongs to the phosphatidylserine decarboxylase family. | 0.665 |
| Cphy_1962 | mprF | Cphy_1962 | Cphy_1959 | TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III delta; KEGG: cth:Cthe_1040 DNA polymerase III, delta subunit. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.403 |
| Cphy_2202 | Cphy_1743 | Cphy_2202 | Cphy_1743 | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Acetoacetate decarboxylase; KEGG: cac:CAC1044 NADH:flavin oxidoreductase, possible NADH oxidase. | 0.574 |
| Cphy_2202 | mprF | Cphy_2202 | Cphy_1959 | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.482 |
| Cphy_2202 | rpoB | Cphy_2202 | Cphy_3687 | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | DNA-directed RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.542 |