STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cphy_2126PFAM: pentapeptide repeat protein; KEGG: mba:Mbar_A3729 hypothetical protein. (200 aa)    
Predicted Functional Partners:
Cphy_2125
PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: bvu:BVU_0072 lactate dehydrogenase and related dehydrogenase.
  
    0.581
Cphy_2124
PFAM: oxidoreductase domain protein; aspartate dehydrogenase; homoserine dehydrogenase NAD-binding; KEGG: pha:PSHAb0019 putative dinucleotide-utilizing enzyme.
       0.562
Cphy_2127
Secreted protein; Contains C-terminal beta-propeller domain distantly related to WD-40 repeats; KEGG: cth:Cthe_2109 copper amine oxidase-like protein.
       0.474
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.468
Cphy_0296
DNA topoisomerase (ATP-hydrolyzing); KEGG: gka:GK0005 DNA gyrase subunit B; PFAM: DNA gyrase subunit B domain protein; ATP-binding region ATPase domain protein; TOPRIM domain protein; DNA topoisomerase type IIA subunit B region 2 domain protein; SMART: DNA topoisomerase II.
   
 
 0.468
Cphy_2948
KEGG: ckl:CKL_3246 hypothetical protein.
  
 
 0.410
Cphy_0068
PFAM: Peptidoglycan-binding LysM; cell wall hydrolase/autolysin; KEGG: syn:slr0891 N-acetylmuramoyl-L-alanine amidase.
 
 
 
 0.408
Your Current Organism:
Lachnoclostridium phytofermentans
NCBI taxonomy Id: 357809
Other names: Clostridium phytofermentans ISDg, L. phytofermentans ISDg, Lachnoclostridium phytofermentans ISDg
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