| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cphy_0002 | Cphy_1352 | Cphy_0002 | Cphy_1352 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | 0.899 |
| Cphy_0002 | Cphy_2205 | Cphy_0002 | Cphy_2205 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | 0.469 |
| Cphy_0002 | Cphy_2365 | Cphy_0002 | Cphy_2365 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: amt:Amet_3681 hypothetical protein. | 0.923 |
| Cphy_0002 | Cphy_3756 | Cphy_0002 | Cphy_3756 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.657 |
| Cphy_0002 | dnaA | Cphy_0002 | Cphy_0001 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.980 |
| Cphy_0002 | polA | Cphy_0002 | Cphy_2803 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.993 |
| Cphy_1352 | Cphy_0002 | Cphy_1352 | Cphy_0002 | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.899 |
| Cphy_1352 | Cphy_2205 | Cphy_1352 | Cphy_2205 | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | 0.434 |
| Cphy_1352 | Cphy_3756 | Cphy_1352 | Cphy_3756 | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.596 |
| Cphy_1352 | polA | Cphy_1352 | Cphy_2803 | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.830 |
| Cphy_2205 | Cphy_0002 | Cphy_2205 | Cphy_0002 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.469 |
| Cphy_2205 | Cphy_1352 | Cphy_2205 | Cphy_1352 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | 0.434 |
| Cphy_2205 | Cphy_2281 | Cphy_2205 | Cphy_2281 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | TIGRFAM: SpoIID/LytB domain protein; PFAM: Stage II sporulation D domain protein; KEGG: amt:Amet_2340 SpoIID/LytB domain protein. | 0.624 |
| Cphy_2205 | Cphy_2365 | Cphy_2205 | Cphy_2365 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | KEGG: amt:Amet_3681 hypothetical protein. | 0.440 |
| Cphy_2205 | Cphy_2985 | Cphy_2205 | Cphy_2985 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | PFAM: zinc finger CHC2-family protein; KEGG: ppd:Ppro_0215 zinc finger, CHC2-family protein. | 0.432 |
| Cphy_2205 | Cphy_3389 | Cphy_2205 | Cphy_3389 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | PFAM: Formamidopyrimidine-DNA glycolase, H2TH DNA binding; KEGG: pdi:BDI_2011 formamidopyrimidine-DNA glycosylase. | 0.412 |
| Cphy_2205 | Cphy_3479 | Cphy_2205 | Cphy_3479 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | TIGRFAM: SpoIID/LytB domain protein; PFAM: Stage II sporulation D domain protein; KEGG: fnu:FN0806 SpoIID homolog. | 0.624 |
| Cphy_2205 | Cphy_3756 | Cphy_2205 | Cphy_3756 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. | 0.895 |
| Cphy_2205 | dnaA | Cphy_2205 | Cphy_0001 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. | 0.542 |
| Cphy_2205 | polA | Cphy_2205 | Cphy_2803 | KEGG: amt:Amet_1757 IstB domain protein ATP-binding protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.664 |