| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Cphy_1729 | Cphy_2284 | Cphy_1729 | Cphy_2284 | TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: mRNA capping enzyme; DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: dsy:DSY0616 hypothetical protein. | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | 0.563 |
| Cphy_1729 | topA | Cphy_1729 | Cphy_2722 | TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: mRNA capping enzyme; DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: dsy:DSY0616 hypothetical protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.714 |
| Cphy_2283 | Cphy_2284 | Cphy_2283 | Cphy_2284 | KEGG: plu:plu1458 unnamed protein product; similar to streptomycin adenyltransferase. | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | 0.727 |
| Cphy_2284 | Cphy_1729 | Cphy_2284 | Cphy_1729 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | TIGRFAM: DNA ligase D; DNA ligase D, 3'-phosphoesterase domain protein; DNA polymerase LigD, polymerase domain protein; DNA polymerase LigD, ligase domain protein; PFAM: mRNA capping enzyme; DNA primase small subunit; ATP dependent DNA ligase domain protein; ATP dependent DNA ligase; KEGG: dsy:DSY0616 hypothetical protein. | 0.563 |
| Cphy_2284 | Cphy_2283 | Cphy_2284 | Cphy_2283 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | KEGG: plu:plu1458 unnamed protein product; similar to streptomycin adenyltransferase. | 0.727 |
| Cphy_2284 | Cphy_2398 | Cphy_2284 | Cphy_2398 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | PFAM: protein of unknown function UPF0102; KEGG: cdf:CD1271 hypothetical protein; Belongs to the UPF0102 family. | 0.495 |
| Cphy_2284 | Cphy_2621 | Cphy_2284 | Cphy_2621 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | KEGG: cth:Cthe_0998 putative membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein. | 0.596 |
| Cphy_2284 | lepA | Cphy_2284 | Cphy_2315 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | GTP-binding protein LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. | 0.609 |
| Cphy_2284 | minE | Cphy_2284 | Cphy_2369 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | Cell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. | 0.649 |
| Cphy_2284 | rnc | Cphy_2284 | Cphy_2444 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. | 0.482 |
| Cphy_2284 | rnhB | Cphy_2284 | Cphy_2400 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.617 |
| Cphy_2284 | secF | Cphy_2284 | Cphy_0716 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.676 |
| Cphy_2284 | topA | Cphy_2284 | Cphy_2722 | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.551 |
| Cphy_2398 | Cphy_2284 | Cphy_2398 | Cphy_2284 | PFAM: protein of unknown function UPF0102; KEGG: cdf:CD1271 hypothetical protein; Belongs to the UPF0102 family. | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | 0.495 |
| Cphy_2398 | rnhB | Cphy_2398 | Cphy_2400 | PFAM: protein of unknown function UPF0102; KEGG: cdf:CD1271 hypothetical protein; Belongs to the UPF0102 family. | Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. | 0.662 |
| Cphy_2398 | secF | Cphy_2398 | Cphy_0716 | PFAM: protein of unknown function UPF0102; KEGG: cdf:CD1271 hypothetical protein; Belongs to the UPF0102 family. | Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.434 |
| Cphy_2398 | topA | Cphy_2398 | Cphy_2722 | PFAM: protein of unknown function UPF0102; KEGG: cdf:CD1271 hypothetical protein; Belongs to the UPF0102 family. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.466 |
| Cphy_2621 | Cphy_2284 | Cphy_2621 | Cphy_2284 | KEGG: cth:Cthe_0998 putative membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein. | KEGG: cth:Cthe_0350 signal peptidase I; TIGRFAM: signal peptidase I; PFAM: peptidase S24 and S26 domain protein. | 0.596 |
| Cphy_2621 | secF | Cphy_2621 | Cphy_0716 | KEGG: cth:Cthe_0998 putative membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein. | Protein-export membrane protein, SecD/SecF family; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. | 0.413 |
| Cphy_2621 | topA | Cphy_2621 | Cphy_2722 | KEGG: cth:Cthe_0998 putative membrane-associated zinc metalloprotease; TIGRFAM: membrane-associated zinc metalloprotease; PFAM: peptidase M50; SMART: PDZ/DHR/GLGF domain protein. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.687 |