STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cphy_2290RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (207 aa)    
Predicted Functional Partners:
Cphy_2497
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.846
Cphy_2498
KEGG: amt:Amet_2512 peptidase S55, sporulation stage IV, protein B; TIGRFAM: stage IV sporulation protein B; PFAM: peptidase S55 SpoIVB; SMART: PDZ/DHR/GLGF domain protein.
  
   
 0.784
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
   
 0.777
Cphy_2385
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.773
Cphy_0479
TIGRFAM: stage V sporulation protein AC; PFAM: SpoVA protein; KEGG: drm:Dred_1106 SpoVA protein.
  
     0.772
Cphy_0481
TIGRFAM: stage V sporulation protein AE; PFAM: SpoVA protein; KEGG: tte:TTE1321 sporulation protein.
  
     0.771
Cphy_2612
PFAM: putative stage IV sporulation YqfD; KEGG: bcy:Bcer98_3032 putative stage IV sporulation YqfD.
  
   
 0.771
Cphy_0480
TIGRFAM: stage V sporulation protein AD; PFAM: Stage V sporulation AD family protein; KEGG: amt:Amet_2220 stage V sporulation AD family protein.
  
     0.770
Cphy_2470
Peptidase U4 sporulation factor SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
 
   
 0.770
Cphy_0135
TIGRFAM: sporulation protein YabP; PFAM: YabP family protein; KEGG: cth:Cthe_2659 YabP-like protein.
  
     0.764
Your Current Organism:
Lachnoclostridium phytofermentans
NCBI taxonomy Id: 357809
Other names: Clostridium phytofermentans ISDg, L. phytofermentans ISDg, Lachnoclostridium phytofermentans ISDg
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