node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cphy_0208 | Cphy_3369 | Cphy_0208 | Cphy_3369 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | PFAM: heat shock protein Hsp90; KEGG: cth:Cthe_0550 heat shock protein HSP90. | 0.975 |
Cphy_0208 | Cphy_3461 | Cphy_0208 | Cphy_3461 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.781 |
Cphy_0208 | clpB | Cphy_0208 | Cphy_3819 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.781 |
Cphy_0208 | dnaK | Cphy_0208 | Cphy_2311 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
Cphy_0208 | groL | Cphy_0208 | Cphy_3289 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.833 |
Cphy_0208 | groS | Cphy_0208 | Cphy_3290 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.768 |
Cphy_0208 | grpE | Cphy_0208 | Cphy_2312 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.914 |
Cphy_0208 | hrcA | Cphy_0208 | Cphy_2313 | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.795 |
Cphy_2171 | Cphy_3369 | Cphy_2171 | Cphy_3369 | PFAM: heat shock protein DnaJ domain protein. | PFAM: heat shock protein Hsp90; KEGG: cth:Cthe_0550 heat shock protein HSP90. | 0.964 |
Cphy_2171 | Cphy_3461 | Cphy_2171 | Cphy_3461 | PFAM: heat shock protein DnaJ domain protein. | PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.713 |
Cphy_2171 | clpB | Cphy_2171 | Cphy_3819 | PFAM: heat shock protein DnaJ domain protein. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.713 |
Cphy_2171 | dnaK | Cphy_2171 | Cphy_2311 | PFAM: heat shock protein DnaJ domain protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.988 |
Cphy_2171 | groL | Cphy_2171 | Cphy_3289 | PFAM: heat shock protein DnaJ domain protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.753 |
Cphy_2171 | groS | Cphy_2171 | Cphy_3290 | PFAM: heat shock protein DnaJ domain protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.601 |
Cphy_2171 | grpE | Cphy_2171 | Cphy_2312 | PFAM: heat shock protein DnaJ domain protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.856 |
Cphy_2171 | hrcA | Cphy_2171 | Cphy_2313 | PFAM: heat shock protein DnaJ domain protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.669 |
Cphy_3369 | Cphy_0208 | Cphy_3369 | Cphy_0208 | PFAM: heat shock protein Hsp90; KEGG: cth:Cthe_0550 heat shock protein HSP90. | PFAM: heat shock protein DnaJ domain protein; KEGG: cbf:CLI_0254 molecular chaperone, DnaJ family. | 0.975 |
Cphy_3369 | Cphy_2171 | Cphy_3369 | Cphy_2171 | PFAM: heat shock protein Hsp90; KEGG: cth:Cthe_0550 heat shock protein HSP90. | PFAM: heat shock protein DnaJ domain protein. | 0.964 |
Cphy_3369 | Cphy_3461 | Cphy_3369 | Cphy_3461 | PFAM: heat shock protein Hsp90; KEGG: cth:Cthe_0550 heat shock protein HSP90. | PFAM: AAA ATPase central domain protein; Clp domain protein; ATPase associated with various cellular activities AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase; KEGG: cth:Cthe_1789 ATPase AAA-2; Belongs to the ClpA/ClpB family. | 0.807 |
Cphy_3369 | clpB | Cphy_3369 | Cphy_3819 | PFAM: heat shock protein Hsp90; KEGG: cth:Cthe_0550 heat shock protein HSP90. | ATP-dependent chaperone ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.807 |