node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cphy_0002 | Cphy_1154 | Cphy_0002 | Cphy_1154 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | 0.766 |
Cphy_0002 | Cphy_1246 | Cphy_0002 | Cphy_1246 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | 0.722 |
Cphy_0002 | Cphy_1352 | Cphy_0002 | Cphy_1352 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | 0.876 |
Cphy_0002 | Cphy_2202 | Cphy_0002 | Cphy_2202 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | 0.480 |
Cphy_0002 | lexA | Cphy_0002 | Cphy_2543 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Transcriptional repressor, LexA family; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.419 |
Cphy_0002 | polA | Cphy_0002 | Cphy_2803 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.997 |
Cphy_0002 | recA | Cphy_0002 | Cphy_2439 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.906 |
Cphy_1154 | Cphy_0002 | Cphy_1154 | Cphy_0002 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.766 |
Cphy_1154 | Cphy_1246 | Cphy_1154 | Cphy_1246 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | 0.956 |
Cphy_1154 | Cphy_1352 | Cphy_1154 | Cphy_1352 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | 0.868 |
Cphy_1154 | Cphy_2202 | Cphy_1154 | Cphy_2202 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | 0.530 |
Cphy_1154 | Cphy_2499 | Cphy_1154 | Cphy_2499 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.430 |
Cphy_1154 | polA | Cphy_1154 | Cphy_2803 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.992 |
Cphy_1154 | recA | Cphy_1154 | Cphy_2439 | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.970 |
Cphy_1246 | Cphy_0002 | Cphy_1246 | Cphy_0002 | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.722 |
Cphy_1246 | Cphy_1154 | Cphy_1246 | Cphy_1154 | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | KEGG: cac:CAC2687 RecQ protein, superfamily II DNA helicase; TIGRFAM: ATP-dependent DNA helicase, RecQ family; ATP-dependent DNA helicase RecQ; PFAM: helicase domain protein; HRDC domain protein; DEAD/DEAH box helicase domain protein; Helicase superfamily 1 and 2 ATP-binding; SMART: DEAD-like helicases. | 0.956 |
Cphy_1246 | Cphy_1352 | Cphy_1246 | Cphy_1352 | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | PFAM: UvrD/REP helicase; KEGG: cth:Cthe_2876 ATP-dependent DNA helicase PcrA. | 0.484 |
Cphy_1246 | Cphy_2202 | Cphy_1246 | Cphy_2202 | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | PFAM: phosphopantetheine-binding; KEGG: ckl:CKL_1730 polyketide synthase-related protein. | 0.470 |
Cphy_1246 | Cphy_2499 | Cphy_1246 | Cphy_2499 | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. | 0.423 |
Cphy_1246 | polA | Cphy_1246 | Cphy_2803 | PFAM: SMC domain protein; KEGG: ctc:CTC00579 exonuclease sbcC. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.983 |