node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cphy_2601 | folD | Cphy_2601 | Cphy_2456 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: cno:NT01CX_1657 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.926 |
Cphy_2601 | purN | Cphy_2601 | Cphy_3468 | PFAM: 5-formyltetrahydrofolate cyclo-ligase; KEGG: cno:NT01CX_1657 5-formyltetrahydrofolate cyclo-ligase family protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.931 |
Cphy_3110 | fhs | Cphy_3110 | Cphy_2752 | KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.802 |
Cphy_3110 | folD | Cphy_3110 | Cphy_2456 | KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.958 |
Cphy_3110 | gcvH | Cphy_3110 | Cphy_1539 | KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.807 |
Cphy_3110 | gcvT | Cphy_3110 | Cphy_1538 | KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.929 |
Cphy_3110 | glyA | Cphy_3110 | Cphy_3274 | KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.946 |
fhs | Cphy_3110 | Cphy_2752 | Cphy_3110 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: swo:Swol_0934 5,10-methylenetetrahydrofolate reductase; TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.802 |
fhs | fmt | Cphy_2752 | Cphy_2491 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.418 |
fhs | fmt-2 | Cphy_2752 | Cphy_3177 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.418 |
fhs | folD | Cphy_2752 | Cphy_2456 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.998 |
fhs | gcvH | Cphy_2752 | Cphy_1539 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.822 |
fhs | gcvT | Cphy_2752 | Cphy_1538 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.942 |
fhs | glyA | Cphy_2752 | Cphy_3274 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.980 |
fhs | purH | Cphy_2752 | Cphy_0643 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | KEGG: cth:Cthe_1246 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: MGS domain protein; AICARFT/IMPCHase bienzyme formylation region. | 0.983 |
fhs | purN | Cphy_2752 | Cphy_3468 | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
fmt | fhs | Cphy_2491 | Cphy_2752 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | PFAM: formate-tetrahydrofolate ligase FTHFS; KEGG: dsy:DSY0205 hypothetical protein; Belongs to the formate--tetrahydrofolate ligase family. | 0.418 |
fmt | fmt-2 | Cphy_2491 | Cphy_3177 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.906 |
fmt | folD | Cphy_2491 | Cphy_2456 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase (NADP(+)); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.965 |
fmt | gcvT | Cphy_2491 | Cphy_1538 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.920 |