STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cphy_2470Peptidase U4 sporulation factor SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family. (293 aa)    
Predicted Functional Partners:
Cphy_2469
RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.965
Cphy_0138
Protein serine/threonine phosphatase; KEGG: cth:Cthe_2681 serine phosphatase; PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein.
  
  
 0.955
Cphy_2468
RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
  
 0.945
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.944
Cphy_3792
TIGRFAM: stage II sporulation protein R; PFAM: Sporulation stage II protein R; KEGG: cbh:CLC_0174 stage II sporulation protein R.
 
   
 0.912
Cphy_0210
TIGRFAM: sporulation transcriptional regulator SpoIIID; KEGG: cth:Cthe_2618 stage III sporulation protein D, SpoIIID.
  
  
 0.892
Cphy_0476
Anti-sigma-factor antagonist; TIGRFAM: anti-anti-sigma factor; anti-sigma F factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; KEGG: amt:Amet_2212 anti-sigma-factor antagonist.
  
  
 0.881
Cphy_2497
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
 
  
 0.874
Cphy_2524
TIGRFAM: stage III sporulation protein AA; SMART: AAA ATPase; KEGG: pth:PTH_1166 hypothetical protein.
  
  
 0.870
Cphy_2316
PFAM: Stage II sporulation P family protein; KEGG: cth:Cthe_1328 stage II sporulation P.
  
   
 0.856
Your Current Organism:
Lachnoclostridium phytofermentans
NCBI taxonomy Id: 357809
Other names: Clostridium phytofermentans ISDg, L. phytofermentans ISDg, Lachnoclostridium phytofermentans ISDg
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