STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cphy_2497Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (266 aa)    
Predicted Functional Partners:
Cphy_2498
KEGG: amt:Amet_2512 peptidase S55, sporulation stage IV, protein B; TIGRFAM: stage IV sporulation protein B; PFAM: peptidase S55 SpoIVB; SMART: PDZ/DHR/GLGF domain protein.
   
 0.953
Cphy_0138
Protein serine/threonine phosphatase; KEGG: cth:Cthe_2681 serine phosphatase; PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein.
  
  
 0.868
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
  
 0.868
Cphy_2468
RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.865
Cphy_2385
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.861
Cphy_0210
TIGRFAM: sporulation transcriptional regulator SpoIIID; KEGG: cth:Cthe_2618 stage III sporulation protein D, SpoIIID.
  
   
 0.857
Cphy_2469
RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
 
   
 0.852
Cphy_2470
Peptidase U4 sporulation factor SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. Belongs to the peptidase U4 family.
 
  
 0.849
Cphy_2290
RNA polymerase, sigma 28 subunit, FliA/WhiG family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.846
Cphy_2524
TIGRFAM: stage III sporulation protein AA; SMART: AAA ATPase; KEGG: pth:PTH_1166 hypothetical protein.
 
   
 0.845
Your Current Organism:
Lachnoclostridium phytofermentans
NCBI taxonomy Id: 357809
Other names: Clostridium phytofermentans ISDg, L. phytofermentans ISDg, Lachnoclostridium phytofermentans ISDg
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