STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase NifS; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (398 aa)    
Predicted Functional Partners:
Cphy_2906
TIGRFAM: FeS cluster assembly scaffold protein NifU; PFAM: nitrogen-fixing NifU domain protein; KEGG: amt:Amet_2454 nitrogen-fixing NifU domain protein.
 
 0.997
thiI
Thiamine biosynthesis/tRNA modification protein ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
  
 0.960
Cphy_3260
KEGG: cbe:Cbei_1494 hypothetical protein.
  
 0.935
Cphy_3470
PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SirA family protein; Rhodanese domain protein; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: drm:Dred_2967 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the sulfur carrier protein TusA family.
   
 
 0.879
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.767
mnmA
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
 
  
 0.702
Cphy_1487
PFAM: SirA family protein; KEGG: cdf:CD3667 hypothetical protein; Belongs to the sulfur carrier protein TusA family.
   
 
 0.700
Cphy_3578
PFAM: UBA/THIF-type NAD/FAD binding protein; KEGG: bay:RBAM_037310 hypothetical protein.
   
 0.686
Cphy_1098
PFAM: Rieske [2Fe-2S] domain protein; FAD dependent oxidoreductase; KEGG: cpf:CPF_0767 iron-sulfur cluster-binding protein, rieske family.
   
 0.684
Cphy_0009
TIGRFAM: transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074; KEGG: csc:Csac_2255 transcriptional regulator, BadM/Rrf2 family.
  
  
 0.608
Your Current Organism:
Lachnoclostridium phytofermentans
NCBI taxonomy Id: 357809
Other names: Clostridium phytofermentans ISDg, L. phytofermentans ISDg, Lachnoclostridium phytofermentans ISDg
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.